87450-10-0

Basic information

• Product Name: Propargyl-PEG5-alcohol
• Synonyms: Propargyl-PEG5-alcohol;Propyne-PEG4-alcohol;3,6,9,12-Tetraoxapentadec-14-yn-1-ol;Alkyne-PEG4-OH;PROPARGYL-PEG5-OH;Propargyl-PEG4-OH
• CAS NO: 87450-10-0
• Molecular Formula: C₁₁H₂₀O₅
• Molecular Weight: 232.2735
• Mol File: 87450-10-0.mol
• Article Data: 66

Chemical Properties

• Boiling Point: 324.4±32.0 °C(Predicted)
• Appearance: /
• Density: 1.071±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 14.36±0.10(Predicted)
• CAS DataBase Reference: Propargyl-PEG5-alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: Propargyl-PEG5-alcohol(87450-10-0)
• EPA Substance Registry System: Propargyl-PEG5-alcohol(87450-10-0)

Safety Data

• Hazardous Substances Data: 87450-10-0(Hazardous Substances Data)

Usage

Description

Propargyl-PEG5-alcohol is a versatile chemical compound that features a propargyl group and a polyethylene glycol (PEG) chain with five repeating units. This molecule is designed to facilitate Click Chemistry reactions with azide compounds or biomolecules through copper-catalyzed azide-alkyne Click Chemistry, resulting in the formation of a stable triazole linkage. The presence of the PEG chain enhances the solubility and biocompatibility of the molecule, making it suitable for various applications in chemical biology and materials science.

Uses

Used in Chemical Biology:
Propargyl-PEG5-alcohol is used as a building block for the synthesis of bioconjugates and probes for biological research. The triazole linkage formed through Click Chemistry ensures stable and specific interactions between the molecule and target biomolecules, allowing for the development of novel tools for studying biological processes and mechanisms.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Propargyl-PEG5-alcohol is used as a component in the design of drug delivery systems. The PEG chain can improve the solubility and bioavailability of drugs, while the triazole linkage allows for the covalent attachment of drug molecules to carriers or nanoparticles. This can lead to enhanced drug targeting, reduced side effects, and improved therapeutic outcomes.
Used in Materials Science:
Propargyl-PEG5-alcohol is utilized as a functionalizing agent for the development of advanced materials with specific properties. The molecule can be incorporated into polymers, gels, or surfaces to introduce new functionalities, such as stimuli-responsive behavior, self-healing properties, or specific binding sites for biomolecules. This can enable the creation of smart materials for various applications, including sensors, actuators, and biomaterials.
Used in Bioorthogonal Chemistry:
In the field of bioorthogonal chemistry, Propargyl-PEG5-alcohol is employed as a reactive handle for the selective labeling and modification of biomolecules within living systems. The copper-catalyzed azide-alkyne Click Chemistry allows for the specific and bioorthogonal reaction between the propargyl group and azide-containing probes, enabling the study of biomolecular dynamics and interactions in a non-disruptive manner.

Upstream product

• 112-60-7 Tetraethylene glycol 
• 96042-30-7 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran 
• 106-96-7 propargyl bromide 
• 624-65-7 2-propynyl chloride 
• 6165-75-9 propargyl benzenesulfonate 
• 6165-76-0 propargyl p-toluenesulfonate 
• 1233816-82-4 C₃₀H₃₄O₅ 

Downstream Products

• 1352144-88-7 C₄₀H₆₀N₆O₁₃ 
• 1397682-61-9 3,6,9,12-tetraoxapentadec-14-ynyl 2,3,4,6-tetra-O-acetyl-β-D-galactopyranoside 
• 1397682-63-1 {2-[2-(2-(2-propyn-1-yloxy)ethoxy)ethoxy]ethoxy}ethyl-β-D-galactopyranoside 
• 1360446-31-6 C₂₅H₃₈O₁₄ 
• 1262681-31-1 C₂₁H₃₅N₃O₆S 
• 24968-11-4 di(3,6,9,12-tetraoxapentadec-14-yn-1-yl) naphthalene-2,6-dicarboxylate 
• 1351556-81-4 2-(2-{2-[2-(2-{2-[2-(2-prop-2-ynyloxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethanol 
• 1429934-37-1 3,6,9,12,15-pentaoxaoctadec-17-ynoic acid 

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