875254-28-7Relevant articles and documents
Ligand-Controlled Direct γ-C?H Arylation of Aldehydes
Ge, Haibo,Lawrence, Brianna,Li, Bijin,Li, Guigen
, p. 3078 - 3082 (2020)
The first example of PdII-catalyzed γ-C(sp3)?H functionalization of aliphatic and benzoheteroaryl aldehydes has been developed using a transient ligand and an external ligand, concurrently. A wide array of γ-arylated aldehydes were readily accessed without preinstalling internal directing groups. The catalytic mechanism was studied by performing deuterium-labelling experiments, which indicated that the γ-C(sp3)?H bond cleavage is the rate-limiting step during the reaction process. This reaction could be performed on a gram scale, and also demonstrated its potential application in the synthesis of new mechanofluorochromic materials with blue-shifted mechanochromic properties.
