876543-82-7Relevant articles and documents
The direct synthesis of N-alkylated amides via a tandem hydration/N-alkylation reaction from nitriles, aldoximes and alcohols
Wang, Nana,Zou, Xiaoyuan,Ma, Juan,Li, Feng
, p. 8303 - 8305 (2014)
A novel strategy for the direct synthesis of N-alkylated amides from nitriles, aldoximes and alcohols was proposed and accomplished in the presence of a Cp*Ir complex. This journal is the Partner Organisations 2014.
A process for preparing N - alkyl amide method (by machine translation)
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Paragraph 0126; 0127; 0128; 0129; 0130, (2017/08/19)
The invention discloses a method for preparing N - alkyl amide of the method. In the reaction container, joins the nitrile, oxime, transition metal catalyst iridium complex [Cp * IrCl2 ]2 , Toluene; the reaction mixture in 100 °C reaction under 6 hours, cooling to room temperature; then the alcohol and alkali compound is added, the reaction mixture in the 130 °C react again under 12 hours later, then through the column separation, to obtain the target compound. The invention from the fully commercialized nitrile, proceed wowo and mellow, in the participation of transition metal iridium catalyst, to directly obtain N - alkyl amide, the reaction exhibits three significant advantages: 1) the use of the commercialization of the starting material; 2) low catalyst load; 3) is environment-friendly and easy to control. Therefore, the reaction in accordance with the requirement of green chemistry, has broad prospects of development. (by machine translation)
