877-89-4

Basic information

• Product Name: 2,4,6-TRIMETHOXY-1,3,5-TRIAZINE
• Synonyms: 2,4,6-Trimethoxy-[1,3,5]-triazin;2,4,6-Trimethoxy-s-triazine;s-Triazine, 2,4,6-trimethoxy-;Trimethyl cyanurate;2,4,6-TRIMETHOXY-1,3,5-TRIAZINE;Methyl cyanurate
• CAS NO: 877-89-4
• Molecular Formula: C₆H₉N₃O₃
• Molecular Weight: 171.15
• EINECS: 212-896-2
• Product Categories: Heterocyclic Compounds;Building Blocks;Heterocyclic Building Blocks;Triazines
• Mol File: 877-89-4.mol
• Article Data: 21

Chemical Properties

• Melting Point: 135-137 °C(lit.)
• Boiling Point: 301.12°C (rough estimate)
• Flash Point: 103.1 °C
• Appearance: /
• Density: 1.3994 (rough estimate)
• Vapor Pressure: 0.00617mmHg at 25°C
• Refractive Index: 1.5800 (estimate)
• PKA: 1.80±0.10(Predicted)
• CAS DataBase Reference: 2,4,6-TRIMETHOXY-1,3,5-TRIAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,6-TRIMETHOXY-1,3,5-TRIAZINE(877-89-4)
• EPA Substance Registry System: 2,4,6-TRIMETHOXY-1,3,5-TRIAZINE(877-89-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 877-89-4(Hazardous Substances Data)

Usage

Description

2,4,6-Trimethoxy-1,3,5-triazine is an organic compound characterized by a triazine ring structure with three methoxy groups attached at the 2nd, 4th, and 6th positions. 2,4,6-TRIMETHOXY-1,3,5-TRIAZINE exhibits unique chemical properties and has been found to be useful in various applications, particularly in analytical chemistry and sample preparation.

Uses

Used in Analytical Chemistry:
2,4,6-Trimethoxy-1,3,5-triazine is used as a molecularly imprinted solid phase extraction (MISPE) agent for the isolation of specific target compounds from complex mixtures. Its molecular imprinting capability allows for selective recognition and separation of target molecules, which is crucial for accurate analysis and detection.
Used in Food Product Analysis:
In the context of food product analysis, 2,4,6-trimethoxy-1,3,5-triazine has been specifically employed for the isolation of melamine (ML), a toxic compound that can contaminate food products and pose serious health risks. The use of this compound in MISPE techniques helps ensure the accurate detection and quantification of melamine, enabling better food safety monitoring and protection of public health.

InChI:InChI=1/C6H9N3O3/c1-10-4-7-5(11-2)9-6(8-4)12-3/h1-3H3

Upstream product

• 67-56-1 methanol 
• 675-14-9 trifluoro-[1,3,5]triazine 
• 108-77-0 1,3,5-trichloro-2,4,6-triazine 
• 124-41-4 sodium methylate 
• 14921-00-7 cyanuric bromide 
• 506-68-3 bromocyane 
• 506-77-4 cyanogen chloride 
• 161870-33-3 2,4,6-tris(trinitromethyl)-1,3,5-triazine 
• 100-21-0 terephthalic acid 
• 27257-90-5 2,4,6-tris(pyrazol-1-yl)-1,3,5-s-triazine 
• 1267550-97-9 C₅₇H₃₀Cl₃N₉O₆ 
• 624-83-9 methyl isocyanate 
• 74-88-4 methyl iodide 
• 109-99-9 tetrahydrofuran 

Downstream Products

• 4255-67-8 N-acetyl-sulfanilic acid-(4,6-dimethoxy-[1,3,5]triazin-2-ylamide) 
• 1075-59-8 2-hydroxy-4,6-dimethoxy-1,3,5-triazine 
• 108-80-5 isocyanuric acid 
• 624-83-9 methyl isocyanate 
• 108-77-0 1,3,5-trichloro-2,4,6-triazine 
• 74-87-3 methylene chloride 
• 1075-59-8 2-hydroxy-4,6-dimethoxy-1,3,5-triazine 
• 16370-63-1 2-amino-4,6-dimethoxy-1,3,5-triazine 
• 4107-73-7 4-amino-N-(4,6-dimethoxy-1,3,5-triazin-2-yl)benzenesulfonamide 

Relevant articles and documents

NUCLEOPHILIC SUBSTITUTION REACTIONS OF 2,4,6-TRIS(TRINITROMETHYL)-1,3,5-TRIAZINE. 1. INTERACTION OF 2,4,6-TRIS(TRINITROMETHYL)-1,3,5-TRIAZINE WITH ALCOHOLS, DIOLS, AMMONIA AND SECONDARY AMINES

A study has been made of nucleophilic substitution reactions of 2,4,6-tris(trinitromethyl)-1,3,5-triazine with certain nucleophiles.The possibility of replacing one, two, or three trinitromethyl groups in this compound has been demonstrated.

USE OF A L,3J5-TRIAZIN-2-YL PHOSPHORAMIDATE COMPOUND IN THE SYNTHESIS OF SOFOSBUVIR

The present invention relates to a new type of 1,3.5-triazin-2-yl phosphoramidates of general formula I with the absolute configuration (S) at the phosphorus atom, an Sp diastereoisomer, wherein R1 and R2 can independently be H, a C1-C6 (un)branched alkyl, a C1-C6 (un)branched alkoxy group, a C1-C6 (un)branched alkylsulfanyl group, C1-C6 (un)branched monoalkylamino or dialkylamino group, including cyclic amino groups, e.g. pyrrolidino, piperidino or morpholino group; and to their use for the production of biologically active phosphoramidate prodrugs, especially sofosbuvir of formula II. Sofosbuvir II is a nucleotide inhibitor of the RNA polymerase, used for the treatment of hepatitis C in the form of a prodrug, releasing the active antiviral agent 2'-deoxy-2'-a-fluoro- P-C-methyluridine-5'-triphosphate in the organism.

Targeting the erythrocytic and liver stages of malaria parasites with s-triazine-based hybrids

A diversity-oriented library of s-triazine-based hybrids was screened for activity against the chloroquine-resistant Plasmodium falciparum W2 strain. The most striking result was sub-micromolar activity against cultured erythrocytic-stage parasites of hybrid molecules containing one or two 8-aminoquinoline moieties. These compounds were not clearly toxic to human cells. The most effective blood-schizontocidal s-triazine derivatives were then screened for activity against the liver stage of malaria parasites. The s-triazine hybrid containing two 8-aminoquinoline moieties and one chlorine atom emerged as the most potent against P. berghei liver-stage infection, active in the low nanomolar region, combined with good metabolic stability in rat liver microsomes. These results indicate that s-triazine-8-aminoquinoline-based hybrids are excellent starting points for lead optimization as dual-stage antimalarials.