87797-63-5Relevant articles and documents
One-pot synthesis of 2,4-disubstituted quinolines via silver-catalyzed three-component cascade annulation of amines, alkyne esters and terminal alkynes
Li, Yunlan,Zhang, Qiurui,Xu, Xuefeng,Zhang, Xu,Yang, Yurong,Yi, Wei
supporting information, p. 965 - 970 (2019/03/13)
Described herein is a new and general method for one-pot synthesis of 2,4-disubstituted quinolines via silver-catalyzed [3 + 1 + 2] annulation of simple amines, alkyne esters and terminal alkynes. The versatile transformation might initiate with the facil
A medicine intermediate quinoline synthetic method of the compound
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Paragraph 0042; 0043; 0044; 0045; 0046; 0047, (2017/08/25)
The invention provides a synthetic method of a quinoline compound as shown in the following formula (III). The method comprises the following steps: in an organic solvent, in existence of a catalyst, an accelerant and alkali, enabling a compound as shown in the formula (I) and a compound as shown in the formula (II) to carry out a reaction, so as to obtain a compound as shown in the formula (III), wherein R is H, C1-C6 alkyl, C1-C6 alkoxy or halogen. According to the method, the plurality of factors such as the catalyst, the accelerant, alkali and the organic solvent are selected, and the target product can be obtained at a high yield, so that the synthetic method can achieve a good industrial application value in the technical field of medical intermediate synthesis.
