878663-15-1

Basic information

• Product Name: C₃₇H₄₂F₃N₃O₄
• CAS NO: 878663-15-1
• Molecular Weight: 649.753
• Mol File: 878663-15-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₇H₄₂F₃N₃O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₇H₄₂F₃N₃O₄(878663-15-1)
• EPA Substance Registry System: C₃₇H₄₂F₃N₃O₄(878663-15-1)

Safety Data

• Hazardous Substances Data: 878663-15-1(Hazardous Substances Data)

Upstream product

• 439660-85-2 6-(3,4-dimethoxy-benzoyl)-cyclohex-3-enecarboxylic acid 
• 935-79-5 cis-1,2,3,6-tetrahydrophthalic anhydride 
• 114446-48-9 -(+)-1-chloro-3-phenyl-3-<4-(trifluoromethyl)phenoxy>propane 
• 100306-34-1 3-chloro-1-phenylpropanol 
• 89980-69-8 3,4-dimethoxyphenylmagnesium bromide 
• 402-45-9 4-hydroxybenzotrifluoride 
• 1116690-31-3 2-(2-bromopentyl)-4-(3,4-dimethoxyphenyl)-4a,5,6,7,8,8a-hexahydrophthalazin-1(2H)-one 
• 130194-43-3 (R)-Norfluoxetine 
• 357980-82-6 4-(3,4-dimethoxy-phenyl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one 
• 878663-12-8 (R)-1-phthalimido-3-(4-trifluormethyl-phenoxy)-3-phenyl-propane 

Relevant articles and documents

Stereoselective inhibition of serotonin re-uptake and phosphodiesterase by dual inhibitors as potential agents for depression

Multi-target compounds where more than one functional activity is incorporated into the same molecule may have advantages in treating disease states. Selective serotonin re-uptake inhibitors (SSRIs)a (i.e., (R)- and (S)-norfluoxetine) were chemically linked to a PDE4 inhibitor via a five carbon bridge. The new dual PDE4 inhibitor/SSRIs (i.e., (R)-8 and (S)-8) showed moderately potent but highly selective serotonin re-uptake inhibition (IC50 values of 173 and 42 nM, respectively) in vitro. The dual PDE4 inhibitor/SSRIs (R)-8 and (S)-8 also inhibited PDE4D2 (i.e., Ki values of 106 and 253 nM, respectively). Due to the synergistic functional activity, PDE4 inhibitor/SSRIs may be effective in treating diseases such as depression.