883560-03-0

Basic information

• Product Name: 2-cyano-3-oxo-3-(4-phenoxy-phenyl)-propionic acid methyl ester
• Synonyms: 2-cyano-3-oxo-3-(4-phenoxy-phenyl)-propionic acid methyl ester
• CAS NO: 883560-03-0
• Molecular Weight: 295.295
• Mol File: 883560-03-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-cyano-3-oxo-3-(4-phenoxy-phenyl)-propionic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-cyano-3-oxo-3-(4-phenoxy-phenyl)-propionic acid methyl ester(883560-03-0)
• EPA Substance Registry System: 2-cyano-3-oxo-3-(4-phenoxy-phenyl)-propionic acid methyl ester(883560-03-0)

Safety Data

• Hazardous Substances Data: 883560-03-0(Hazardous Substances Data)

Upstream product

• 2215-77-2 4-Phenoxybenzoic acid 
• 105-34-0 methyl 2-cyanoacetate 

Downstream Products

• 883560-04-1 2-(4-phenoxy-phenyl)-pyrazolo[1,5-a]pyrimidine-6-carbonitrile 
• 501902-74-5 5-(4-phenoxy-phenyl)-1H-pyrazol-3-ylamine 
• 136562-77-1 3-oxo-3-(4-phenoxyphenyl)propanenitrile 

Relevant articles and documents

Novel non-benzimidazole chk2 kinase inhibitors

In a recent paper, [Arienti, K. L.; Brunmark, A.; Axe, F. U.; McClure, K. M.; Lee, A.; Blevitt, J.; Neff, D. K.; Huang, L.; Crawford, S.; Chennagiri, R. P.; Karlsson, L.; Brietenbucher, J. G. J. Med. Chem. 2005, 48, 1873], we described the discovery of a class of benzimidazole chk2 kinase inhibitors, exemplified by compound 1, which had radio-protective effects in human T-cells subjected to ionizing radiation. Here, a series of non-benzimidazole analogs intended to define the scope of the SAR about this new series of inhibitor, and allow for refinement of the binding model of these compounds to the chk2 kinase is described.