88413-26-7Relevant articles and documents
OXIDATION DYES
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, (2008/06/13)
The invention relates to oxidation colorants which are particularly suitable for coloring keratin fiber and to a method of coloring such fiber. The colorants contain as the preliminary oxidation dye at least one diamino aniline of the general formula (I), in which R1 to R6 independently of each other are hydrogen, a (C1-C4)-alkyl group, a hydroxy-(C2-C3)-alkyl group, a (C1-C4)-alkoxy-(C2-C3)-alkyl group, an amino-(C2-C3)-alkyl group in which the amino group can also have one or two (C1-C4)-alkyl radicals, or a 2,3-dihydroxypropyl group provided that not all substituents R1 to R6 are simultaneously hydrogen, and R1 and R2 and/or R3 and R4 and/or R5 and R6 along with the nitrogen atom to which they are attached are also an aziridine ring, an azetidine ring, a pyrrolidine ring, a piperidine ring, an azepane ring, an azocine ring or a morpholino group, thiomorpholino group or piperazino group which has another substituent R7 on the nitrogen atom which is selected from hydrogen, a (C1-C4)-alkyl group, a hydroxy-(C2-C3)-alkyl group, a (C1-C4)-alkoxy-(C2-C3)-alkyl group, an amino-(C2-C3)-alkyl group, or a 2,3-dihydroxypropyl group, and the three remaining hydrogen atoms on the benzol ring can also be replaced independently of each other by a halogen atom or a (C1-C4)-alkyl group, or the physiologically tolerable salts thereof with inorganic and organic acids. Shades of color are obtained which have a high level of brilliancy and color fastness.
Potential Antitumor Agents. 48. 3'-Dimethylamino Derivatives of Amsacrine: Redox Chemistry and in Vivo Tumor Activity
Atwell, Graham J.,Rewcastle, Gordon W.,Baguley, Bruce C.,Denny, William A.
, p. 652 - 658 (2007/10/02)
Structure-activity relationships for a series of acridine-substituted 3'-N(CH3)2 derivatives of the clinical antileukemic drug amsacrine (1) are reported.The parent (unsubstituted) compound 3 has activity against the Lewis lung solid tumor that is superior to amsacrine(1), the new clinical amsacrine analogue 4, and the recently developed 3'-NHCH3 derivative 2.Although the compounds generally bind less well to DNA and are less dose potent in vivo than either their amsacrine (3'-OCH3) or 3'-NHCH3 analogues, they show very high levels of antitumor activity, with the 4-OCH3 derivative capable of effecting 100percent cures of the Lewis lung solid tumor.The broad structure-activity relationships for acridine substitution more closely resemble those of the amsacrine than the 3'-NHCH3 series, with 4-substituted and 4,5-disubstituted compounds showing the highest activity.
