88612-90-2

Basic information

• Product Name: CYCLOPROPANECARBOXYLIC ACID, 2-(4-NITROPHENYL), ETHYL ESTER
• Synonyms: CYCLOPROPANECARBOXYLIC ACID, 2-(4-NITROPHENYL), ETHYL ESTER
• CAS NO: 88612-90-2
• Molecular Formula: C₁₂H₁₃NO₄
• Molecular Weight: 0
• Mol File: 88612-90-2.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: CYCLOPROPANECARBOXYLIC ACID, 2-(4-NITROPHENYL), ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: CYCLOPROPANECARBOXYLIC ACID, 2-(4-NITROPHENYL), ETHYL ESTER(88612-90-2)
• EPA Substance Registry System: CYCLOPROPANECARBOXYLIC ACID, 2-(4-NITROPHENYL), ETHYL ESTER(88612-90-2)

Safety Data

• Hazardous Substances Data: 88612-90-2(Hazardous Substances Data)

Upstream product

• 623-73-4 diazoacetic acid ethyl ester 
• 100-13-0 4-nitrostyrene 
• 586-78-7 para-nitrophenyl bromide 
• 946-38-3 cis-1-ethoxycarbonyl-2-phenylcyclopropane 
• 946-39-4 ethyl rac-(1S,2S)-2-phenylcycloproanecarboxylate 
• 186581-53-3 diazomethane 
• 555-16-8 4-nitrobenzaldehdye 
• 100-42-5 styrene 

Downstream Products

• 1206479-02-8 ethyl 5-(4-nitrophenyl)-4,5-dihydroisoxazole-3-carboxylate 
• 159670-70-9 ethyl 5-(4-nitrophenyl)isoxazole-3-carboxylate 
• 16633-46-8 trans-2-(p-Nitrophenyl-)cyclopropanecarboxylic acid 
• 141794-89-0 ethyl cis-2-(p-aminophenyl)-1-cyclopropanecarboxylate 
• 141794-89-0 (1R*,2R*)-ethyl 2-(4-aminophenyl)cyclopropanecarboxylate 

Relevant articles and documents

QUINOLIN-4-ONE AND 4(1H)-CINNOLINONE COMPOUNDS AND METHODS OF USING SAME

The present disclosure relates to quinolin-4-one and 4(1H)-cinnolinone compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into tissue cells.

Multigram Synthesis and C?C/C?N Couplings of Functionalized 1,2-Disubstituted Cyclopropyltrifluoroborates

A convenient approach to the multigram synthesis of functionalized 1,2-disubstituted cyclopropyltrifluoroborates was developed, based on Pd(II)- or Cu(I)-catalyzed reaction of vinyltrifluoroborate and diazo compounds. Optimized protocols allowed for the preparation of the target products as pure diastereomers on multigram scale. It was shown that the title compounds were good coupling partners for the Suzuki-Miyaura and Chan-Lam reactions, which provide medicinally relevant (het)arylcyclopropanes with high diastereoselectivity. (Figure presented.).

Engineering of RuMb: Toward a Green Catalyst for Carbene Insertion Reactions

The small, stable heme protein myoglobin (Mb) was modified through cofactor substitution and mutagenesis to develop a new catalyst for carbene transfer reactions. The native heme was removed from wild-type Mb and several Mb His64 mutants (H64D, H64A, H64V), and the resulting apoproteins were reconstituted with ruthenium mesoporphyrin IX (RuMpIX). The reconstituted proteins (RuMb) were characterized by UV-vis and circular dichroism spectroscopy and were used as catalysts for the N-H insertion of aniline derivatives and the cyclopropanation of styrene derivatives. The best catalysts for each reaction were able to achieve turnover numbers (TON) up to 520 for the N-H insertion of aniline, and 350 TON for the cyclopropanation of vinyl anisole. Our results show that RuMb is an effective catalyst for N-H insertion, with the potential to further increase the activity and stereoselectivity of the catalyst in future studies. Compared to native Mb ("FeMb"), RuMb is a more active catalyst for carbene transfer reactions, which leads to both heme and protein modification and degradation and, hence, to an overall much-reduced lifetime of the catalyst. This leads to lower TONs for RuMb compared to the iron-containing analogues. Strategies to overcome this limitation are discussed. Finally, comparison is also made to FeH64DMb and FeH64AMb, which have not been previously investigated for carbene transfer reactions.