886496-63-5

Basic information

• Product Name: 2-Bromo-5-(trifluoromethyl)benzyl bromide
• Synonyms: 1-Bromo-2-(bromomethyl)-4-(trifluoromethyl)benzene, 4-Bromo-3-(bromomethyl)benzotrifluoride
• CAS NO: 886496-63-5
• Molecular Formula: C₈H₅Br₂F₃
• Molecular Weight: 317.9285096
• Product Categories: Fluorine series
• Mol File: 886496-63-5.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 259℃
• Flash Point: 110℃
• Appearance: /
• Density: 1.885
• Vapor Pressure: 0.0219mmHg at 25°C
• Refractive Index: 1.523
• CAS DataBase Reference: 2-Bromo-5-(trifluoromethyl)benzyl bromide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-5-(trifluoromethyl)benzyl bromide(886496-63-5)
• EPA Substance Registry System: 2-Bromo-5-(trifluoromethyl)benzyl bromide(886496-63-5)

Safety Data

• Hazardous Substances Data: 886496-63-5(Hazardous Substances Data)

Usage

General Description

2-Bromo-5-(trifluoromethyl)benzyl bromide is a chemical compound with the molecular formula C8H5Br2F3. It is a colorless liquid that is commonly used as a reagent in organic synthesis, specifically in the preparation of various pharmaceuticals and agrochemicals. 2-Bromo-5-(trifluoromethyl)benzyl bromide is highly reactive due to the presence of the bromine and trifluoromethyl functional groups, making it useful for introducing these groups into organic molecules. It is also known for its ability to act as a strong halogenating agent in various chemical reactions. However, it is important to handle this compound with care, as it is toxic and can cause skin and eye irritation upon contact.

InChI:InChI=1/C8H5Br2F3/c9-4-5-3-6(8(11,12)13)1-2-7(5)10/h1-3H,4H2

Upstream product

• 75-09-2 dichloromethane 
• 402-05-1 2-bromo-5-(trifluoromethyl)phenol 
• 929000-62-4 1-bromo-2-methyl-4-(trifluoromethyl)benzene 
• 1483-56-3 2-bromo-5-(trifluoromethyl)benzoic acid 
• 869725-53-1 (2-bromo-5-(trifluoromethyl)phenyl)methanol 

Downstream Products

• 1246444-73-4 1-(2-bromo-5-(trifluoromethyl)benzyloxy)-2-methylpropan-2-ol 
• 1274905-22-4 2-(5-((2-bromo-5-(trifluoromethyl)benzyl)oxy)-2-chlorophenyl)-2-isopropyl-3-methylbutanenitrile 
• 1185737-41-0 [6-methoxy-2'-((4S,5R)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-ylmethyl)-4'-trifluoromethyl-biphenyl-3-yl]-acetic acid 
• 1185737-33-0 [2'-((4S,5R)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-ylmethyl)-4'-trifluoromethyl-biphenyl-3-yl]-acetic acid 
• 1347747-08-3 C₂₅H₂₀F₃NO₄ 
• 1185737-53-4 [6-methoxy-2'-((4S,5R)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-ylmethyl)-4'-trifluoromethyl-biphenyl-3-yl]-acetic acid ethyl ester 
• 1347747-10-7 C₂₇H₂₄F₃NO₄ 
• 1347747-12-9 C₂₆H₂₂F₃NO₄ 
• 1347747-14-1 C₂₇H₂₄F₃NO₄ 
• 1347747-16-3 C₂₅H₂₂FNO₄ 
• 875446-37-0 anacetrapib 
• 869725-65-5 2-allyl-1-bromo-4-(trifluoromethyl)benzene 
• 16238-03-2 2-phenyl-5-(trifluoromethyl)benzofuran 
• 1185737-46-5 2-[6-methoxy-2'-((4S,5R)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-ylmethyl)-4'-trifluoromethyl-biphenyl-3-yl]-propionic acid 

Relevant articles and documents

2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS

The present invention relates to Nav1.8 Inhibitor 2,3-dihydroquinazolin compounds of Formula (X); wherein Y', X', B', R1', R2', R3', R5', R6', R7', and z1 are as defined herein; or pharmaceutically acceptable salts or tautomer forms thereof, corresponding pharmaceutical compositions or formulations, methods or processes of compound preparation, methods, compounds for use in, uses for and/or combination therapies for treating pain and/or pain-related or associated disease(s), disorder(s) or condition(s), respectively.

tBuOK-Promoted Cyclization of Imines with Aryl Halides

A transition-metal-free indole synthesis using radical coupling of 2-halotoluenes and imines via the later-stage C-N bond construction was reported for the first time. It includes an aminyl radical generation by C-H cleaving addition of 2-halotoluenes to imines via the carbanion radical relay and an intramolecular coupling of aryl halides with aminyl radicals. One standard condition can be used for all halides including F, Cl, Br, and I. No extra oxidant or transition metal is required.

Strategy for Overcoming Full Reversibility of Intermolecular Radical Addition to Aldehydes: Tandem C-H and C-O Bonds Cleaving Cyclization of (Phenoxymethyl)arenes with Carbonyls to Benzofurans

An intermolecular addition of carbon radicals enabled by a cascade radical coupling strategy is developed. It includes an intermolecular alkyl radical addition to a carbonyl group followed by an intramolecular alkoxy radical addition to haloarenes and produces substituted benzofurans in high yields. The radical nature of this reaction is explored by radical trapping experiments and EPR analysis. The mechanism is investigated by KIE experiments and control experiments. This method could provide rapid and practical access to the key intermediate of TAM-16, a safe and potent antibacterial agent for treating tuberculosis, and, therefore, is of great importance for organic synthesis and the pharmaceutical industry.