887581-09-1

Basic information

• Product Name: 2-BROMO-5-METHOXYBENZYLAMINE
• Synonyms: 2-BROMO-5-METHOXYBENZYLAMINE;(2-BROMO-5-METHOXYPHENYL)METHANAMINE
• CAS NO: 887581-09-1
• Molecular Formula: C₈H₁₀BrNO
• Molecular Weight: 216.08
• Product Categories: Anilines, Aromatic Amines and Nitro Compounds
• Mol File: 887581-09-1.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 2-BROMO-5-METHOXYBENZYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-5-METHOXYBENZYLAMINE(887581-09-1)
• EPA Substance Registry System: 2-BROMO-5-METHOXYBENZYLAMINE(887581-09-1)

Safety Data

• Hazardous Substances Data: 887581-09-1(Hazardous Substances Data)

Upstream product

• 138642-47-4 2-bromo-5-methoxybenzonitrile 
• 7507-86-0 2-bromo-5-methoxy-benzaldehyde 
• 19614-12-1 2-bromo-5-methoxybenzyl bromide 
• 99848-43-8 2-bromo-5-methoxybenzamide 

Downstream Products

• 478375-35-8 tert-butyl (2-bromo-5-methoxybenzyl)carbamate 
• 1108177-20-3 N-(2-bromo-5-methoxybenzyl)benzenesulfonamide 
• 1173893-64-5 C₁₂H₁₄BrNO₂ 
• 1255516-32-5 2-(4-fluorophenyl)-6-methoxyquinazoline 
• 1255516-31-4 6-methoxy-2-(4-methoxyphenyl)quinazoline 
• 34637-66-6 6-methoxy-2-phenylquinazoline 
• 1255516-35-8 6-methoxy-2-(4-nitrophenyl)quinazoline 
• 1255516-30-3 6-methoxy-2-(p-tolyl)quinazoline 
• 1357295-74-9 1-(2-bromo-5-methoxybenzyl)-5-hexyl-3,4-dihydropyridin-2(1H)-one 
• 1357295-70-5 1-(2-bromo-5-methoxybenzyl)-5-(4-methylbenzyl)-3,4-dihydropyridin-2(1H)-one 
• 1357295-81-8 8-methoxy-1-(4-methylbenzyl)-2,6-dihydropyrido[2,1-a]isoindol-4(3H)-one 

Relevant articles and documents

Synthesis of a unique isoindoline/tetrahydroisoquinoline-based tricyclic sultam library utilizing a Heck-aza-Michael strategy

The synthesis of a unique isoindoline- and tetrahydroisoquinoline (THIQ)-containing tricyclic sultam library, utilizing a Heck-aza-Michael (HaM) strategy is reported. Both isoindoline and THIQ rings are installed through a Heck reaction on a vinylsulfonamide, followed by one-pot deprotection and intramolecular aza-Michael reaction. Subsequent cyclization with either paraformaldehyde condensation or 1,1′-carbonyldiimidazole coupling generates a variety of tricyclic sultams. Overall, a 160-member library of these sultams, together with their isoindolines/THIQ and secondary sulfonamides precursors, were constructed using this strategy.

MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS

The present invention relates to macrocyclic compounds of Formula I: or pharmaceutically acceptable salts thereof or quaternary ammonium salts thereof wherein constituent members are provided hereinwith, as well as their compositions and methods of use, which are JAK/ALK inhibitors useful in the treatment of JAK/ALK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer.

An efficient preparation of N-alkyl-2-benzazepine derivatives and investigation of their biological activity

N-Alkyl-2-benzazepine derivatives are readily prepared through N-alkylation of secondary 2-benzazepines that are constructed via 7-endo selective cyclization of radical cyclization of N-boc-N-(2-bromo-5-methoxyphenylmethyl) methacrylamides. The structure