888-19-7

Basic information

• Product Name: 1-[2-(1H-indol-3-yl)ethyl]pyrrolidin-2-one
• CAS NO: 888-19-7
• Molecular Formula: C₁₄H₁₆N₂O
• Molecular Weight: 228.2896
• Mol File: 888-19-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 478°C at 760 mmHg
• Flash Point: 242.9°C
• Density: 1.22g/cm³
• Vapor Pressure: 2.66E-09mmHg at 25°C
• Refractive Index: 1.65
• CAS DataBase Reference: 1-[2-(1H-indol-3-yl)ethyl]pyrrolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[2-(1H-indol-3-yl)ethyl]pyrrolidin-2-one(888-19-7)
• EPA Substance Registry System: 1-[2-(1H-indol-3-yl)ethyl]pyrrolidin-2-one(888-19-7)

Safety Data

• Hazardous Substances Data: 888-19-7(Hazardous Substances Data)

Usage

Chemical structure

A derivative of pyrrolidin-2-one with an indole group attached to the ethyl side chain

Indole group

A bicyclic aromatic organic compound consisting of a six-membered benzene ring fused to a five-membered nitrogen-containing pyrrole ring

Pharmacological properties

Potential effects on the central nervous system

Potential use

As a psychoactive substance in medicine

Research status

Further research is needed to fully understand its chemical and biological properties and potential applications

Upstream product

• 125260-53-9 tert-butyl 3-[2-(piperidin-1-yl)ethyl]-1H-indole-1-carboxylate 
• 61-54-1 tryptamine 
• 2969-81-5 Ethyl 4-bromobutyrate 

Downstream Products

• 14008-96-9 3-(2-(pyrrolidin-1-yl)ethyl)-1H-indole 

Relevant articles and documents

Transition-Metal-Free Deconstructive Lactamization of Piperidines

One of the major challenges in organic synthesis is the activation or deconstructive functionalization of unreactive C(sp3)–C(sp3) bonds, which requires using transition or precious metal catalysts. We present here an alternative: the deconstructive lactamization of piperidines without using transition metal catalysts. To this end, we use 3-alkoxyamino-2-piperidones, which were prepared from piperidines through a dual C(sp3)–H oxidation, as transitory intermediates. Experimental and theoretical studies confirm that this unprecedented lactamization occurs in a tandem manner involving an oxidative deamination of 3-alkoxyamino-2-piperidones to 3-keto-2-piperidones, followed by a regioselective Baeyer–Villiger oxidation to give N-carboxyanhydride intermediates, which finally undergo a spontaneous and concerted decarboxylative intramolecular translactamization.

New bis-indolic macrolactams

Treatment of several ω-halogenoamides, derived from tryptamine, with powdered potassium hydroxide in 1,2-dimethoxyethane in the presence of 18-crown-6, resulted in intramolecular and/or bimolecular cyclization, depending on the length of the chain and dilution conditions, to give macrocyclic compounds. Some of them were converted by a Bischler-Napieralski reaction, followed or not by reduction, to new tetracyclic derivatives of β-carbolines.