89013-88-7

Basic information

• Product Name: Pyridine, 4-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-
• CAS NO: 89013-88-7
• Molecular Formula: C14H11N3O2
• Molecular Weight: 253.26
• Mol File: 89013-88-7.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Pyridine, 4-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 4-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-(89013-88-7)
• EPA Substance Registry System: Pyridine, 4-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-(89013-88-7)

Safety Data

• Hazardous Substances Data: 89013-88-7(Hazardous Substances Data)

Upstream product

• 55-22-1 pyridine-4-carboxylic acid 
• 1570-45-2 isonicotinic acid ethylester 
• 14389-12-9 5-(4-pyridyl)tetrazole 
• 100-07-2 4-methoxy-benzoyl chloride 
• 100-09-4 4-methoxybenzoic acid 
• 54-85-3 isoniazid 
• 123-11-5 4-methoxy-benzaldehyde 
• 151427-25-7 N-isonicotinoyl-N'-(4-methoxybenzoyl)hydrazine 

Relevant articles and documents

Synthesis of Pyridine Clubbed 2,5-Disubstituted-1,3,4-Oxadiazole Derivatives Shows Potent Antimicrobial Activity

In the present study, a series of 2,5-disubstituted-1,3,4 oxadiazole analogues retaining pyridine moiety were synthesized (4a-j) by reacting various substituted aromatic acids and isonicotinohydrazide by using POCl3 as a cycling agent. The structure elucidation of all the synthesized compounds was done by chromatographic data and spectral data analysis. The synthesized compounds were evaluated for their in-vitro antimicrobial activity against various strains of ESKAPE pathogens. Antibacterial activity was performed against Bacillus subtilis, Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa, while antifungal activity was assayed against Candida albicans and Aspergillus spp. The result of in-vitro antimicrobial studies of all the synthesized compounds revealed that compound 4d and 4f exhibited promising activity against selected microbial strains equally compared to Cefixime and Econazole used as reference drugs.

Synthesis and biological screening of Some 1,3,4-oxadiazoles

Treatment of Schiff bases with yellow mercuric oxide and iodine in DMF medium yields the title compounds 1,3,4-oxadiazoles (4a-j). The structures of the newly synthesized compounds were assigned on the basis of IR, 1H NMR, Mass spectral data and elemental analysis. All the new compounds were evaluated for their in vitro antibacterial and antifungal activity. Some of the new compounds showed good activity against some bacteria when compared with the standard drug.

A facile procedure for the one-pot synthesis of unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles

Unsymmetrically 2,5-disubstituted 1,3,4-oxadiazoles were efficiently synthesized from the cyclization-oxidation reaction of acyl hydrazones. Also, the synthesis of the title compounds was achieved by the condensation of acyl hydrazides and aromatic aldehydes in the presence of ceric ammonium nitrate in dichloromethane.