89108-75-8

Basic information

• Product Name: 1,8-Naphthyridin-2(1H)-one, 3-(cyclohexylmethyl)-4-hydroxy-1-phenyl-
• CAS NO: 89108-75-8
• Molecular Formula: C21H22N2O2
• Molecular Weight: 334.418
• Mol File: 89108-75-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,8-Naphthyridin-2(1H)-one, 3-(cyclohexylmethyl)-4-hydroxy-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,8-Naphthyridin-2(1H)-one, 3-(cyclohexylmethyl)-4-hydroxy-1-phenyl-(89108-75-8)
• EPA Substance Registry System: 1,8-Naphthyridin-2(1H)-one, 3-(cyclohexylmethyl)-4-hydroxy-1-phenyl-(89108-75-8)

Safety Data

• Hazardous Substances Data: 89108-75-8(Hazardous Substances Data)

Upstream product

• 10094-36-7 ethyl 3-cyclohexylpropanoate 
• 51269-84-2 methyl 2-phenylamino-nicotinate 
• 62-53-3 aniline 
• 40134-18-7 methyl 2-chloropyridine-3-carboxylate 

Relevant articles and documents

Antiallergy Agents. 1. Substituted 1,8-Naphthyridin-2(1H)-ones as Inhibitors of SRS-A Release

A novel class of antiallergy agents, the substituted 1,8-naphthyridin-2(1H)-ones, is described.The present compounds are orally active, potent inhibitors of allergic and nonallergic bronchospasm in animal models.Structure-activity studies of the lead compound in this sereis, 1-phenyl-3-n-butyl-4-hydroxynaphthyridin-2(1H)-one (11), identified three compounds of interest, 1-phenyl-3-(2-propenyl)-4-acetoxy-1,8-naphthyridin-2(1H)-one (12), 1-(3'-chlorophenyl)-3-(2-propenyl)-4-acetoxy-1,8-naphthyridin-2(1H)-one (87), and 1-(3'-methoxyphenyl)-3-(2-propenyl)-4-acetoxy-1,8-naphthyridin-2(1H)-one (89).The mechanism of antiallergy activity may involve inhibition of the release of the sulfidopeptide leukotrienes. 1-Phenyl-3-(2-propenyl)-4-acetoxy-1,8-naphthyridin-2(1H)-one, Sch 33303 (12), was selected for preclinical development as an antiallergy agent.