89534-52-1Relevant articles and documents
Convenient procedure for the indium-mediated hydroxymethylation of active bromo compounds: Transformation of ketones into α-hydroxymethyl nitroalkanes
Soengas, Raquel G.,Estévez, Amalia M.
supporting information; experimental part, p. 2625 - 2627 (2010/12/18)
A very simple, safe and powerful method for the hydroxymethylation of 2-bromoesters and lactones under anhydrous conditions that avoids the use of gaseous formaldehyde is described. Moreover, under these conditions, bromonitroalkanes were converted into the corresponding α- monohydroxymethylated nitroalkanes, which are precursors of the corresponding α-amino acids. Considering the easy transformation of ketones into bromonitroalkanes, this represents a method for the formal synthesis of α-amino acids from ketones. Georg Thieme Verlag Stuttgart New York.
Enantioselective Reduction of 2-Methyl-3-oxopropionate by Bakers' Yeast
Nakamura, Kaoru,Miyai, Takehiko,Ushio, Kazutoshi,Oka, Shinzaburo,Ohno, Atsuyoshi
, p. 2089 - 2094 (2007/10/02)
Various esters of 2-methyl-3-oxopropionic acid were subjected to the reduction with bakers' yeast.Effects of size and bulkiness as well as hydrophobicity of alcohol moieties of the substrates on the enantioselectivity of the reduction were investigated.The substrates having bulky ester groups gave the (R)-hydroxy esters with high enantioselectivities.A mechanism to alter the stereoselectivity of the reduction is proposed.
