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897365-81-0

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897365-81-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 897365-81-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,9,7,3,6 and 5 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 897365-81:
(8*8)+(7*9)+(6*7)+(5*3)+(4*6)+(3*5)+(2*8)+(1*1)=240
240 % 10 = 0
So 897365-81-0 is a valid CAS Registry Number.

897365-81-0Downstream Products

897365-81-0Relevant articles and documents

Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction

Ding, Ke,Lu, Yipin,Nikolovska-Coleska, Zaneta,Wang, Guoping,Qiu, Su,Shangary, Sanjeev,Gao, Wei,Qin, Dongguang,Stuckey, Jeanne,Krajewski, Krzysztof,Roller, Peter P.,Wang, Shaomeng

, p. 3432 - 3435 (2006)

Potent, specific, non-peptide small-molecule inhibitors of the MDM2-p53 interaction were successfully designed. The most potent inhibitor (MI-63) has a Ki value of 3 nM binding to MDM2 and greater than 10 000-fold selectivity over Bcl-2/Bcl-xL

SPIRO-OXINDOLE MDM2 ANTAGONISTS

-

, (2012/05/21)

Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as

SPIRO-OXINDOLE MDM2 ANTAGONISTS

-

, (2011/05/16)

Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as

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