897365-81-0Relevant articles and documents
Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction
Ding, Ke,Lu, Yipin,Nikolovska-Coleska, Zaneta,Wang, Guoping,Qiu, Su,Shangary, Sanjeev,Gao, Wei,Qin, Dongguang,Stuckey, Jeanne,Krajewski, Krzysztof,Roller, Peter P.,Wang, Shaomeng
, p. 3432 - 3435 (2006)
Potent, specific, non-peptide small-molecule inhibitors of the MDM2-p53 interaction were successfully designed. The most potent inhibitor (MI-63) has a Ki value of 3 nM binding to MDM2 and greater than 10 000-fold selectivity over Bcl-2/Bcl-xL
SPIRO-OXINDOLE MDM2 ANTAGONISTS
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, (2012/05/21)
Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as
SPIRO-OXINDOLE MDM2 ANTAGONISTS
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, (2011/05/16)
Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as