89763-51-9Relevant articles and documents
INHIBITORS OF ACETYL-COA CARBOXYLASE
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Page/Page column 40, (2010/11/17)
The present invention relates to compounds that act as acetyl-CoA carboxylase (ACC) inhibitors. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.
Radioprotectors
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, (2008/06/13)
Use of a compound of formula (I): wherein X is optionally substituted aminoalkyl, optionally substituted alkylene or an interactive group; Y and Z may be the same or different and are selected from N, O, S and C(R′) wherein R′ is hydrogen, optionally substituted alkyl or optionally substituted alkenyl; ----is a double bond unless the attached Y or Z group is O or S in which case it is a single bond; and R1to R11may be the same or different and are selected from hydrogen, a sterically hindering group and an electron donating group; or any two of R1to R11, Y, Z, NH and R′ may together with the carbon atoms to which they are attached form an optionally substituted ring which may contain heteroatoms, provided that at least one of R1to R11is an electron donating group and that when X is NCH3, Y and Z are N and R1, R2and R4to R11are hydrogen, then R3is not OH or OCH2CH3; and salts thereof, pharmaceutically acceptable derivatives thereof, pro-drugs thereof and/or tautomers thereof, as a radioprotector. Also provided is a method of protecting a subject from radiation damage, a method of protecting biological materials from damage caused by radiation or cytotoxic agents and certain novel compounds of formula (I). Processes for the preparation of the novel compounds of formula (I) are also provided.