89976-75-0

Basic information

• Product Name: 6-AMINO-2H-1,4-BENZOXAZIN-3(4H)-ONE
• Synonyms: 6-AMINO-4H-BENZO[1,4]OXAZIN-3-ONE;6-AMINO-2H-1,4-BENZOXAZIN-3(4H)-ONE;2H-1,4-benzoxazin-3(4H)-one, 6-amino-;6-Amino-2H-1,4-benzoxin-3(4H)-one;6-amino-2H-1,4-benzoxazin-3(4H)-one(SALTDATA: FREE);6-Amino-3,4-dihydro-3-oxo-2H-1,4-benzoxazine;6-Amino-3-oxo-3,4-dihydrobenzo[1,4]oxazine;6-AMino-3,4-dihydro-2H-1,4-benzoxazin-3-one
• CAS NO: 89976-75-0
• Molecular Formula: C₈H₈N₂O₂
• Molecular Weight: 164.16
• Mol File: 89976-75-0.mol
• Article Data: 17

Chemical Properties

• Melting Point: 266-268°C
• Boiling Point: 429.2 °C at 760 mmHg
• Flash Point: 213.4 °C
• Appearance: /
• Density: 1.344
• Vapor Pressure: 1.43E-07mmHg at 25°C
• Refractive Index: 1.624
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 6-AMINO-2H-1,4-BENZOXAZIN-3(4H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-AMINO-2H-1,4-BENZOXAZIN-3(4H)-ONE(89976-75-0)
• EPA Substance Registry System: 6-AMINO-2H-1,4-BENZOXAZIN-3(4H)-ONE(89976-75-0)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-52-22
• Safety Statements: 26-36/37/39-24/25
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 89976-75-0(Hazardous Substances Data)

Usage

General Description

6-Amino-2H-1,4-benzoxazin-3(4H)-one is a chemical compound that belongs to the benzoxazinone class of compounds. It is a heterocyclic compound containing a benzene ring fused to an oxazine ring with an amino group attached at the 6th position. 6-Amino-2H-1,4-benzoxazin-3(4H)-one has been studied for its potential biological activities, including its role as a natural defense compound in plants and its potential as an anti-cancer agent. Additionally, 6-Amino-2H-1,4-benzoxazin-3(4H)-one has been investigated for its potential use in pharmaceuticals and agrochemicals. Its chemical structure and properties make it a subject of interest in various fields of research.

InChI:InChI=1/C8H8N2O2/c9-5-1-2-7-6(3-5)10-8(11)4-12-7/h1-3H,4,9H2,(H,10,11)

Upstream product

• 85196-33-4 ethyl 2,4-dinitrophenoxyacetate 
• 598-42-5 glycolamide 
• 95-76-1 m,p-dichloroaniline 
• 67-56-1 methanol 
• 100135-98-6 (4-acetylamino-2-nitro-phenoxy)-acetic acid ethyl ester 
• 2298-36-4 4-aminophenoxyacetic acid 
• 81721-87-1 6-nitro-4H-benzo[1,4]oxazin-3-one 
• 25141-25-7 2,4-dinitrophenoxyacetic acid 
• 90814-92-9 N-(3-oxo-3,4-dihydro-2H-benz[1,4]oxazin-6-yl)-acetamide 
• 99-57-0 2-hydroxy-5-nitroaniline 

Downstream Products

• 31794-45-3 3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-sulfonyl chloride 
• 866132-09-4 C₁₅H₁₂N₂O₄ 
• 888038-17-3 1-phenyl-piperidine-4-carboxylic acid (3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-amide 
• 26011-57-4 3,4-Dihydro-2H-benzo[1,4]oxazin-6-ylamine 
• 1025717-56-9 3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)-N-(3,4-dihydro-3-oxo-2H-benzo[b][1,4]oxazin-6-yl)-4-methylbenzamide trifluoroacetate 
• 868593-15-1 N-{2-[ethyl(3-methylphenyl)amino]ethyl}-N'-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)urea 
• 1421843-09-5 C₂₁H₁₆FN₅O₂ 
• 1403816-31-8 6-((5-phenyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)amino)-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 1403818-29-0 methyl 3-(7-((3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)amino)-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzoate 
• 1403817-75-3 6-((5-(4-methoxyphenyl)-1H-pyrazolo[4,3-d]pyrimidin-7-yl)amino)-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 1403816-20-5 6-((5-(3,4-dimethoxyphenyl)-1H-pyrazolo[4,3-d]pyrimidin-7-yl)amino)-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 1395026-64-8 6-(2-chlorophenyl)-2-[(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)amino]imidazo[1,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one trifluoroacetate 

Relevant articles and documents

METHOD FOR PRODUCING 6-AMINO-2H-1,4-BENZOXAZINE-3(4H)-ONE

PROBLEM TO BE SOLVED: To provide an industrially advantageous production method for 6-amino-2H-1,4-benzoxazine-3(4H)-one. SOLUTION: A method for producing 6-amino-2H-1,4-benzoxazine-3(4H)-one includes contact reduction and cyclization of the following compound, using a catalyst containing one or more metal atom selected from the group consisting of iron, cobalt, nickel and copper (R1 is a C1-C6 alkyl group; R2, R3 and R4 are the same or different to denote a C1-C6 alkyl group, a halogen atom or H). SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT

METHOD OF PRODUCING 6-AMINO-2H-1,4-BENZOXAZINE-3(4H)-ONES

PROBLEM TO BE SOLVED: To provide an industrially advantageous method of producing 6-amino-2H-1,4-benzoxazine-3(4H)-ones. SOLUTION: There is provided a method of producing a compound represented by formula (2) by catalytic reduction and cyclization of a compound represented by formula (1), where R1 is C1-C6 alkyl, and R2-R4 are C1-C6 alkyl, halogen or H. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT

NOVEL FUSED PYRIDINE DERIVATIVES USEFUL AS FAK/AURORA KINASE INHIBITORS

This invention relates to certain novel pyrimidine derivatives of the Formula (I). The invention also relates to process for the preparation of the compound of the formula (I), pharmaceutical agents or compositions containing the compound or a method of using the compound for the treatment of proliferative diseases, such as cancer.