90-45-9Relevant articles and documents
Preparation method of 9-aminoacridine and derivatives thereof
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Paragraph 0043-0047; 0057-0060, (2020/05/01)
The invention relates to a preparation method of 9-aminoacridine and derivatives thereof, and belongs to the technical field of organic synthesis. The preparation method of 9-aminoacridine and derivatives thereof comprises the following steps: adding a compound represented by a formula III into a polar aprotic solvent, then introducing a compound represented by a formula II, carrying out a reaction at a temperature of 70-120 DEG C, and after the reaction is finished, separating and purifying an obtained reaction solution to obtain 9-aminoacridine represented by a formula I and the derivativesthereof. The preparation method can be used for preparing the final product by a one-pot method, and is short in synthetic route, simple and convenient to operate, free of intermediates, high in yieldand low in cost. The method has the advantages of mild reaction conditions, low solvent corrosivity, low price, easy availability and recyclability, ensures the long-term operation of reaction equipment, enhances the operation safety factor, further lowers the production cost, and is suitable for large-scale production and application.
9-Substituted acridines as effective corrosion inhibitors for mild steel: Electrochemical, surface morphology, and computational studies
Li, Hui-Jing,Liu, Ying,Wang, Li-Juan,Wu, Yan-Chao,Zhang, Weiwei,Zhang, Yinlin
, p. 6464 - 6474 (2020/05/13)
Three 9-substituted acridines, namely 9-carboxyacridine (CA), 9-methylacridine (MA), and 9-aminoacridine (AA), were designed and synthesized for the development of effective inhibitors for mild steel corrosion in a 15% HCl solution. The corrosion-resistance ability was tested by weight-loss tests, electrochemical techniques, surface-topography analyses (SEM, SECM, and XPS), and contact angle measurements. The results indicated the inhibition performance followed the order of η(AA) > η(MA) > η(CA), and these acridines acted as mixed type inhibitors with a predominant restrained cathode process. The adsorption of the three acridines on a mild steel surface obeyed the Langmuir adsorption isotherm and involved both physisorption and chemisorption modes. Surface analysis and characterization confirmed the existence of an adsorbed film. Quantum chemical calculations were performed to provide mechanistic insights into the roles of the different substituents (-COOH, -CH3, and -NH2) on the corrosion-inhibition behavior of the three acridines. Molecular dynamics (MD) simulations were carried out to explore the configurational adsorption behavior of these 9-substituted acridines on the Fe(110) surface.
Imine acridine derivative fluorescent probe as well as preparation method and application thereof in detection of MORAb-3-1 antibodies
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, (2018/11/22)
The invention discloses an imine acridine derivative fluorescent probe as well as a preparation method and application thereof in detection of MORAb-3-1 antibodies. A detection method of the MORAb-3-1antibody is established by combining specificities of antigens and antibodies. The detection method of the MORAb-3-1 antibody has the technical effects that 1, an imine acridine derivative biologicalprobe is combined with HSA (human serum albumin), and then combined with the MORAb-3-1 antibody for the first time, and the MORAb-3-1 antibody is observed under a fluorescent inverted microscope; 2,the combination of the probe and the antigen is judged by utilizing the photophysical and photochemistry natures; 3, the sensitivity is high, the operation is simple, convenient and rapid, and the accuracy is realized; compared with the traditional dye method, the advantages are more excellent. The formula is shown in the description.