90-83-5

Basic information

• Product Name: Racephedrine
• Synonyms: Benzenemethanol, alpha-((1R)-1-(methylamino)ethyl)-, (alphas)-rel-;Benzenemethanol, alpha-(1-(methylamino)ethyl)-, (R*,S*)-(+-)- (9ci);Brn 3197916;Einecs 202-017-0
• CAS NO: 90-83-5
• Molecular Formula: C10H15NO
• Molecular Weight: 165.23
• Mol File: 90-83-5.mol
• Article Data: 82

Chemical Properties

• Boiling Point: 255 °C at 760 mmHg
• Flash Point: 85.6 °C
• Appearance: /
• Density: 1.015 g/cm³
• CAS DataBase Reference: Racephedrine(CAS DataBase Reference)
• NIST Chemistry Reference: Racephedrine(90-83-5)
• EPA Substance Registry System: Racephedrine(90-83-5)

Safety Data

• Hazardous Substances Data: 90-83-5(Hazardous Substances Data)

Usage

General Description

Racephedrine is a pharmaceutical chemical that acts as a bronchodilator and decongestant. It is a racemic mixture of the two enantiomers of ephedrine, with similar pharmacological effects. Racephedrine is commonly used in over-the-counter medications for the treatment of symptoms related to asthma, bronchitis, and other respiratory conditions. Its mechanism of action involves stimulating the adrenergic receptors in the bronchial smooth muscles, leading to relaxation and dilation of the airways. However, due to its potential for abuse and side effects such as increased heart rate and blood pressure, its use is restricted in some countries.

Upstream product

• 5650-44-2 methcathinone 
• 90-63-1 (RS)-1-hydroxy-1-phenylpropan-2-one 
• 74-89-5 methylamine 
• 93-55-0 1-phenyl-propan-1-one 
• 50-00-0 formaldehyd 
• 492-41-1 (1R,2S)-norephedrine 
• 90-81-3 ephedrine 
• 127-09-3 sodium acetate 
• 94133-42-3 (+)-Chloroephedine hydrochloride 
• 62-23-7 4-nitro-benzoic acid 
• 77387-33-8 (1R,2S)-(-)-N-formylnorephedrine 
• 7647-01-0 hydrogenchloride 
• 90-82-4 pseudoephedrine 
• 10035-10-6 hydrogen bromide 

Downstream Products

• 110195-71-6 ((1S,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-((Ξ)-β-hydroxy-phenethyl)-methyl-amine 
• 100608-88-6 3ξ-[((1S,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amino]-acrylaldehyde 
• 113750-46-2 (+/-)-3,4r-dimethyl-2ξ-octyl-5c-phenyl-oxazolidine 
• 91049-48-8 (4R,5S)-3,4-dimethyl-5-phenyloxazolidin-2-one 
• 112532-00-0 (1S,2R)-(-)-ephedrinium (S)-(+)-mandelate 
• 494846-57-0 (-)-trans-(1S,3S)-2,2-dimethyl-3-phenylcyclopropanecarboxylic acid 
• 124226-71-7 6-methyl-9,10-didehydro-ergoline-8β-carboxylic acid-[((1S,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide] 
• 103397-84-8 bis-((1Ξ,2S)-2-methylamino-1-phenyl-propyl)-ether 
• 6402-25-1 L-erythro-2-methylamino-1-(4-amino-phenyl)-propanol-⁽¹⁾ 
• 42511-08-0 (+)-hexahydro-pseudoephedrine 
• 36298-43-8 3,4-dimethyl-2,5-diphenyl-oxazolidine 
• 42511-08-0 (1S,2R)-1-cyclohexyl-2-methylamino-propan-1-ol 
• 42511-08-0 (1RS,2SR)-1-cyclohexyl-2-methylamino-propan-1-ol 
• 147146-41-6 (2R,4S,5R)-2-(2-chlorophenyl)-3,4-dimethyl-5-phenyloxazolidine 

Relevant articles and documents

Process for preparing beta-aminoalcohol from terminal olefin

The invention provides a method for preparing beta-aminoalcohol from terminal olefin. The method comprises the following steps: with the terminal olefin as a raw material, adding dibromohydantoin, conducting stirring, and then adding organic amine to obtain corresponding beta-aminoalcohol. The method has the advantages of mild conditions, easy operation, cheap raw materials, and wide application prospect.

Peroxygenase-Catalysed Epoxidation of Styrene Derivatives in Neat Reaction Media

Biocatalytic oxyfunctionalisation reactions are traditionally conducted in aqueous media limiting their production yield. Here we report the application of a peroxygenase in neat reaction conditions reaching product concentrations of up to 360 mM.

Evaluation of the Edman degradation product of vancomycin bonded to core-shell particles as a new HPLC chiral stationary phase

A modified macrocyclic glycopeptide-based chiral stationary phase (CSP), prepared via Edman degradation of vancomycin, was evaluated as a chiral selector for the first time. Its applicability was compared with other macrocyclic glycopeptide-based CSPs: TeicoShell and VancoShell. In addition, another modified macrocyclic glycopeptide-based CSP, NicoShell, was further examined. Initial evaluation was focused on the complementary behavior with these glycopeptides. A screening procedure was used based on previous work for the enantiomeric separation of 50 chiral compounds including amino acids, pesticides, stimulants, and a variety of pharmaceuticals. Fast and efficient chiral separations resulted by using superficially porous (core-shell) particle supports. Overall, the vancomycin Edman degradation product (EDP) resembled TeicoShell with high enantioselectivity for acidic compounds in the polar ionic mode. The simultaneous enantiomeric separation of 5 racemic profens using liquid chromatography-mass spectrometry with EDP was performed in approximately 3?minutes. Other highlights include simultaneous liquid chromatography separations of rac-amphetamine and rac-methamphetamine with VancoShell, rac-pseudoephedrine and rac-ephedrine with NicoShell, and rac-dichlorprop and rac-haloxyfop with TeicoShell.