9002-61-3

Basic information

• Product Name: Chorionic gonadotrophin
• Synonyms: HCG;HCG, HUMAN;HCG, INTACT;HUMAN CHORIONIC GONADOTROPHIN;HUMAN CHORIONIC GONADOTROPIN;CHORIONIC GONADOTROPIN, HUMAN URINE;CHORIONIC GONADOTROPIN HORSE;CHORIONIC GONADOTROPIN HUMAN
• CAS NO: 9002-61-3
• Molecular Formula: C17H28
• Molecular Weight: 232.40422
• EINECS: 232-660-2
• Product Categories: Diagnostic reagents;Cytokine
• Mol File: 9002-61-3.mol
• Article Data: 0

Chemical Properties

• Appearance: /lyophilized powder
• Storage Temp.: 2-8°C
• Solubility: H2O: soluble1ML/vial
• CAS DataBase Reference: Chorionic gonadotrophin(CAS DataBase Reference)
• NIST Chemistry Reference: Chorionic gonadotrophin(9002-61-3)
• EPA Substance Registry System: Chorionic gonadotrophin(9002-61-3)

Safety Data

• Hazard Codes: B,Xn
• Statements: 63-62
• Safety Statements: 22-36-36/37
• WGK Germany: 3
• RTECS: MD6953000
• Hazardous Substances Data: 9002-61-3(Hazardous Substances Data)

Usage

Description

Chorionic gonadotrophin (hCG) is a glycoprotein hormone composed of a 92-amino acid α-chain, which is identical to that of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and thyroid-stimulating hormone (TSH), and a distinct 149-amino acid β-chain. It is produced by chorionic tissue and plays a crucial role in maintaining the corpus luteum during early pregnancy. Additionally, it is produced by trophoblast cell neoplasms, which are characterized by elevated free hCG β-chains and hyperglycosylated hCG.

Uses

Used in Reproductive Applications:
Chorionic gonadotrophin is used as a fertility treatment to induce oocyte maturation in cultured follicles. It is also used in combination with pregnant mare serum gonadotropin (PMSG) to induce superovulation in mice, which helps in the production of a higher number of eggs for in vitro fertilization or other assisted reproductive techniques.
Used in Hormone Therapy:
Chorionic gonadotrophin is used as a medium component for fetal testes culture to aid steroidogenic responsiveness. This application is particularly useful in the study of hormone production and regulation in the testes, as well as in the development of treatments for hormonal imbalances.
Used in Cancer Detection:
Due to its production by trophoblast cell neoplasms, elevated levels of free hCG β-chains and hyperglycosylated hCG can be used as biomarkers for the detection and monitoring of certain types of cancer, such as testicular and ovarian cancers.
Brand names of Chorionic gonadotrophin include A.P.L. (Ferring Pharmaceuticals), Follutein (Bristol-Myers Squibb), and Pregnyl (Organon).

Production Methods

CG is produced in the chorion.

Biochem/physiol Actions

Elevated levels of hCG is observed in trophoblastic cancer. hCG levels are indicators of pregnancy and β subunit is majorly present in urine samples. hCG isoform detection is useful in the diagnosis and management of trophoblastic related diseases including carcinomas.

Clinical Use

Choriogonadotropin alfa is obtained by rDNA technology and is biologically and chemically identical to hCG of natural origin. It is used, like hCG of natural origin, for inducing ovulation in women with anovulatory infertility. Following proper pretreatment with a GnRH antagonist or superagonist to desensitize the pituitary, women participating in ART are treated with a folliclestimulating agent (e.g., menotropins) to effect the final maturation of the follicles within the ovaries. Ultrasonograms are used to determine proper follicle maturation before the administration of choriogonadotropin alfa to induce ovulation. A distinct advantage of this product is that it can be self-administered by the patient via SC injection.

Veterinary Drugs and Treatments

The veterinary product’s labeled indication is for “parenteral use in cows for the treatment of nymphomania (frequent or constant heat) due to cystic ovaries.” It has been used for other purposes in several species; refer to the Dosage section for more information.