9004-66-4 Usage
Description
Iron-dextran is a dark brown, slightly viscous liquid complex of ferric hydroxide and dextran, used for intravenous or intramuscular administration. It serves as a hematinic for the treatment of patients with documented iron deficiency where oral administration is unsatisfactory or impossible.
Uses
Used in Human and Veterinary Medicine:
Iron-dextran is used as a parenteral treatment for iron-deficiency anemia in both humans and baby pigs, addressing cases where oral iron supplementation is insufficient or infeasible.
Used in Research:
Iron-dextran can be utilized as a reagent and may be employed to induce iron-overload in experimental settings, allowing researchers to study its effects and develop preventative measures or treatments for conditions associated with iron overload.
History
The therapeutic value of colloidal iron preparations was first reported in the 1950's by London and Twigg. Numerous attempts have been made to improve these iron preparations Thus dextran ([h] 0.05) is first heated with alkali, and is then neutralized in the presence of ferric chloride solution. Studies on this product have revealed that each particle consists of a central iron core, approximately 3nm diameter, surrounded by a dextran sheath of approximately 13nm diameter. The complex is visualized as a particle formed by a protective sheath of dextran attached by terminal metasaccharinic acid units to a b-FeOOH core. A solution of this complex containing 5% iron and 20% dextran (Imferon ? ) is suitable for intramuscular and intravenous injection for treating iron deficiency anemia. The product is currently used widely for treating anemia in new-born piglets.
The use of these preparations has been re-examined in humans and a dramatic rise in hemoglobin was reported following intravenous infusion. The solution is best administered together with glucose solutions.
Reactivity Profile
Iron-dextran is unstable at a pH of 5 and decomposes at 149-158° F. Iron-dextran may be sensitive to prolonged exposure to air.
Health Hazard
SYMPTOMS: The symptoms associated with exposure to Iron-dextran are headaches, vomiting, and dizziness.
Fire Hazard
Iron-dextran is combustible.
Clinical Use
Prophylaxis of iron deficiency anaemia (when oral
treatment is ineffective or contraindicated)
Treatment of iron deficiency during ESA therapy
especially if serum ferritin is very low (<50
nanograms/mL)
Drug interactions
Potentially hazardous interactions with other drugs
Dimercaprol: avoid concomitant use.
Oral iron: reduced absorption of oral iron
Carcinogenicity
Iron dextran complex is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
Metabolism
After intravenous infusion, iron dextran is taken up by
the cells of the reticuloendothelial cells, particularly in the
liver and spleen. The reticuloendothelial cells gradually
separate iron from the iron-dextran complex. Most
absorbed iron is bound to transferrin and transported
to the bone marrow where it is incorporated into
haemoglobin; the remainder is contained within the
storage forms, ferritin or haemosiderin, or as myoglobin,
with smaller amounts occurring in haem-containing
enzymes or in plasma bound to transferrin.
Only very small amounts of iron are excreted as the
majority released after the destruction of the haemoglobin
molecule is re-used.
Check Digit Verification of cas no
The CAS Registry Mumber 9004-66-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,0 and 4 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 9004-66:
(6*9)+(5*0)+(4*0)+(3*4)+(2*6)+(1*6)=84
84 % 10 = 4
So 9004-66-4 is a valid CAS Registry Number.