901-36-0

Basic information

• Product Name: (1S,4aS)-6-Methoxy-1,4a-diMethyl-9-oxo-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylic acid
• Synonyms: LY-180299; methyl 12-methoxy-7-oxopodocarpa-8,11,13-trien-15-oate; methyl 12-methoxy-7-oxopodocarpa-8,11,13-trien-16-oate
• CAS NO: 901-36-0
• Molecular Formula: C₁₉H₂₄O₄
• Molecular Weight: 302.36488
• Mol File: 901-36-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 438.8°Cat760mmHg
• Flash Point: 191.8°C
• Appearance: /
• Density: 1.131g/cm³
• Vapor Pressure: 6.71E-08mmHg at 25°C
• Refractive Index: 1.531
• CAS DataBase Reference: (1S,4aS)-6-Methoxy-1,4a-diMethyl-9-oxo-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,4aS)-6-Methoxy-1,4a-diMethyl-9-oxo-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylic acid(901-36-0)
• EPA Substance Registry System: (1S,4aS)-6-Methoxy-1,4a-diMethyl-9-oxo-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylic acid(901-36-0)

Safety Data

• Hazardous Substances Data: 901-36-0(Hazardous Substances Data)

Usage

Description

(1S,4aS)-6-Methoxy-1,4a-diMethyl-9-oxo-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylic acid is a complex organic chemical compound characterized by a phenanthrene ring system and a carboxylic acid functional group. It features a methoxy group and two methyl groups attached to different carbon atoms, contributing to its unique molecular structure. (1S,4aS)-6-Methoxy-1,4a-diMethyl-9-oxo-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylic acid may hold potential in medicinal chemistry and drug development due to the biological activities observed in similar compounds.

Uses

Used in Medicinal Chemistry:
(1S,4aS)-6-Methoxy-1,4a-diMethyl-9-oxo-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylic acid is utilized as a compound of interest in medicinal chemistry for its potential biological activities. Its unique structure, including the phenanthrene ring and functional groups, may contribute to its interactions with biological targets, warranting further research into its therapeutic applications.
Used in Drug Development:
In the field of drug development, (1S,4aS)-6-Methoxy-1,4a-diMethyl-9-oxo-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylic acid is considered a candidate molecule for the design and synthesis of new pharmaceutical agents. Its complex structure and functional groups may offer advantages in targeting specific biological pathways or mechanisms, which could lead to the development of novel treatments for various diseases.
Further research is necessary to fully understand the properties and potential uses of this compound, as its complex molecular structure and the presence of various functional groups suggest a wide range of possible applications in both medicinal chemistry and drug development.

InChI:InChI=1/C19H24O4/c1-18-8-5-9-19(2,17(21)23-4)16(18)11-15(20)13-7-6-12(22-3)10-14(13)18/h6-7,10,16H,5,8-9,11H2,1-4H3/t16-,18-,19+/m1/s1

Upstream product

• 1231-74-9 methyl 12-methoxypodocarpa-8,11,13-trien-19-oate 
• 4614-56-6 methyl podocarpate 
• 5947-49-9 podocarpic acid 
• 74-85-1 ethene 
• 501-65-5 diphenyl acetylene 
• 623-43-8 methyl crotonate 
• 292638-85-8 acrylic acid methyl ester 
• 107-02-8 acrolein 
• 107-13-1 acrylonitrile 
• 78-94-4 methyl vinyl ketone 
• 1045-54-1 6α-Brom-7-oxo-O-methylpodocarpsaeure-methylester 
• 1231-74-9 methyl O-methylpodocarpate 

Downstream Products

• 33169-07-2 (1S,4aS,10aR)-1,4a-Dimethyl-6-oxo-1,2,3,4,4a,6,7,8,10,10a-decahydro-phenanthrene-1-carboxylic acid 
• 64597-69-9 (1S,2R,3S)-3-(2,5-Dimethoxy-phenyl)-2-methoxycarbonylmethyl-1,3-dimethyl-cyclohexanecarboxylic acid methyl ester 
• 23526-52-5 methyl 12-methoxypodocarpa-6,8,11,13-tetraen-19-oate 
• 23526-53-6 methyl 7β-hydroxy-12-methoxypodocarpa-8,11,13-trien-19-oate 
• 64597-67-7 (1S,2R,3S)-3-(2-Hydroxy-5-methoxy-phenyl)-2-methoxycarbonylmethyl-1,3-dimethyl-cyclohexanecarboxylic acid methyl ester 
• 1865-97-0 methyl O-methyl-Δ^5,6-7-ketopodocarpate 
• 1045-54-1 6α-Brom-7-oxo-O-methylpodocarpsaeure-methylester 

Relevant articles and documents

Phenolic diterpenoid derivatives as anti-influenza a virus agents

A series of diterpenoid derivatives based on podocarpic acid were synthesized and evaluated as anti-influenza A virus agents. Several of the novel podocarpic acid derivatives exhibited nanomolar activities against an H1N1 influenza A virus (A/Puerto Rico/8/34) that was resistant to two anti-influenza drugs, oseltamivir and amantadine. This class of compounds inhibits the influenza virus by targeting the viral hemagglutinin-mediated membrane fusion. These results indicated that podocarpic acid derivatives may serve as potential drug candidates to fight drug-resistant influenza A virus infections.

Skeletal rearrangements of ring C aromatic diterpenoids

The structure of a naphthalene derivative obtained by rearrangement of 13-methoxytotara-5,8,11,13-tetraen-7α-ol (2) has been revised to 5-(5′-isopropyl-6′-methoxy-2′-methyl-1′-naphthyl)-2- methylpent-2-ene (7). A minor oxidation product of 13-methoxytotar

Reactions of η2-tetracarbonylmanganese complexes derived from podocarpic acid with electrophiles; functionalization of ring C

Reaction of tetracarbonylmanganese(I) complexes derived from podocarpic acid (1) with electrophilic bromine or iodine in CCl4 leads to 14-halogenated derivatives inaccessible by direct halogenation.Similar reactions in protic solvents lead to the formation of γ-lactones in high yield.The structure of one of these was established unequivocally by X-ray crystallograohy.Attempted oxidation of the C-Mn bond with a number of reagents proved generally to be unsuccessful.