90101-16-9 Usage
Description
Droxicam is an orally-active prodrug of piroxicam, a non-steroidal anti-inflammatory drug (NSAID), used in the treatment of spinal osteoarthritis. It possesses a pharmacological profile comparable to piroxicam but has a significantly lower ulcerogenic effect, making it a safer alternative. In addition to its therapeutic benefits, droxicam exhibits analgesic and antipyretic activities in animal studies, without causing any adverse cardiovascular or respiratory effects.
Uses
Used in Pharmaceutical Industry:
Droxicam is used as a non-steroidal anti-inflammatory drug (NSAID) for its anti-inflammatory, analgesic, and antipyretic properties. It is particularly effective in the treatment of spinal osteoarthritis, providing relief from pain, inflammation, and fever associated with the condition.
Used in Pain Management:
Droxicam is used as a pain management agent for its analgesic properties, helping to alleviate pain and discomfort in various conditions, including spinal osteoarthritis and other inflammatory disorders.
Used in Antipyretic Therapy:
Droxicam is used as an antipyretic agent to reduce fever and associated symptoms in patients with inflammatory conditions or infections.
Used in Inflammatory Conditions:
Droxicam is used as an anti-inflammatory agent to manage inflammation in various conditions, such as spinal osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis, among others.
Used in Gastrointestinal Protection:
Due to its lower ulcerogenic effect compared to other NSAIDs, droxicam is used as a gastrointestinal protective agent, offering a safer alternative for patients with a history of gastrointestinal issues or at risk of developing them while on NSAID therapy.
Originator
Esteve (Spain)
World Health Organization (WHO)
Droxicam is authorized to be marketed in many European
countries. Although droxicam is metabolized to piroxicam, it is considered that the risk of hepatic damage differs from that shown by other NSAIDs products,
including piroxicam.
Check Digit Verification of cas no
The CAS Registry Mumber 90101-16-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,0,1,0 and 1 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 90101-16:
(7*9)+(6*0)+(5*1)+(4*0)+(3*1)+(2*1)+(1*6)=79
79 % 10 = 9
So 90101-16-9 is a valid CAS Registry Number.
InChI:InChI=1/C16H11N3O5S/c1-18-13-14(10-6-2-3-7-11(10)25(18,22)23)24-16(21)19(15(13)20)12-8-4-5-9-17-12/h2-9H,1H3
90101-16-9Relevant articles and documents
Triphosgene in heterocyclic chemistry: A novel synthesis of the antiinflammatory prodrug droxicam
Bracher, Franz,Berns, Caroline
, p. 477 - 478 (1997)
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Process for the preparation of oxazinobenzothiazine 6,6-dioxide derivatives
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, (2008/06/13)
The present invention relates to a process for the preparation of a 5-methyl-3-heteroaryl-2H,5H-1,3-oxazino[5,6-c] [1,2] benzothiazine-2,4-(3H)-dione 6,6-dioxide of the general formula I: STR1 in which R represents a heteroraryl radical, preferably substituted or unsubstituted pyrimidinyl or pyridyl, of the type consisting in reacting an amide of the general formula II: STR2 in which R1 represents a heteroarylamino radical, preferably substituted or unsubstituted pyrimidinylamino or pyridylamino, with a compound of the general formula III: STR3 in which R2 represents a C1 to C4 lower alkyl radical such as methyl or ethyl, an aryl radical such as phenyl, or an alkylaryl radical such as benzyl, wherein the reaction is carried out in an organic solvent selected from the group comprising pyridine, substituted pyridines such as 4-dimethylaminopyridine, 4-(pyrrolidin-1-yl)pyridine and 2,6-ditert.-butyl-4-methylpyridine, and mixtures thereof.
