903557-28-8

Basic information

• Product Name: 4-bromo-2,3-dihydro-1H-inden-1-amine
• Synonyms: 4-bromo-2,3-dihydro-1H-inden-1-amine;4-BROMO-2,3-DIHYDRO-1H-INDEN-1-AMINE HYDROCHLORIDE;4-Bromo-1-indanamine HCl
• CAS NO: 903557-28-8
• Molecular Formula: C₉H₁₀BrN
• Molecular Weight: 212.09
• Mol File: 903557-28-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 276.0±40.0 °C(Predicted)
• Appearance: /
• Density: 1.490±0.06 g/cm3(Predicted)
• PKA: 8.88±0.20(Predicted)
• CAS DataBase Reference: 4-bromo-2,3-dihydro-1H-inden-1-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-2,3-dihydro-1H-inden-1-amine(903557-28-8)
• EPA Substance Registry System: 4-bromo-2,3-dihydro-1H-inden-1-amine(903557-28-8)

Safety Data

• Hazardous Substances Data: 903557-28-8(Hazardous Substances Data)

Usage

General Description

4-bromo-2,3-dihydro-1H-inden-1-amine is a chemical compound with the molecular formula C9H10BrN. It is an amine derivative with a bromine atom attached to the carbon ring. 4-bromo-2,3-dihydro-1H-inden-1-amine is used in medicinal chemistry and pharmaceutical research as a building block for the synthesis of various bioactive molecules and pharmaceuticals. Its unique structure and functional groups make it a versatile intermediate for the development of new drugs and biologically active compounds. Additionally, its potential therapeutic applications include its use as a neurotransmitter reuptake inhibitor, making it a promising candidate for the treatment of neurological disorders and psychiatric conditions. As a result, 4-bromo-2,3-dihydro-1H-inden-1-amine is a valuable compound in the field of drug discovery and development.

Upstream product

• 15115-60-3 4-bromo-2,3-dihydroinden-1-one 
• 903557-27-7 4-bromo-1-indanone oxime 

Downstream Products

• 1228556-71-5 (S)-4-bromo-2,3-dihydro-1H-inden-1-amine 

Relevant articles and documents

Deconstructive Oxygenation of Unstrained Cycloalkanamines

A deconstructive oxygenation of unstrained primary cycloalkanamines has been developed for the first time using an auto-oxidative aromatization promoted C(sp3)?C(sp3) bond cleavage strategy. This metal-free method involves the substitution reaction of cycloalkanamines with hydrazonyl chlorides and subsequent auto-oxidative annulation to in situ generate pre-aromatics, followed by N-radical-promoted ring-opening and further oxygenation by 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) and m-cholorperoxybenzoic acid (mCPBA). Consequently, a series of 1,2,4-triazole-containing acyclic carbonyl compounds were efficiently produced. This protocol features a one-pot operation, mild reaction conditions, high regioselectivity and ring-opening efficiency, broad substrate scope, and is compatible with alkaloids, osamines, and peptides, as well as steroids.

Microwave-accelerated reductive amination between ketones and ammonium acetate

A new procedure for reductive amination between ketones and ammonium acetate has been developed to access a variety of primary amines. This protocol takes advantage of microwave heating to significantly accelerate the reaction and offers a convenient and effective method to access some interesting amines. This new procedure compares favorably to previously reported approaches in terms of practicality, efficiency, and functional group compatibility.

THERAPEUTIC FLUOROETHYLCYANO GUANIDINES

Disclosed herein is compound having a formula as described herein. Therapeutic methods, compositions, and medicaments related thereto are also disclosed.