905118-28-7

Basic information

• Product Name: 3-fluoro-benzoic acid N'-chloroacetyl-hydrazide
• CAS NO: 905118-28-7
• Molecular Weight: 230.626
• Mol File: 905118-28-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-fluoro-benzoic acid N'-chloroacetyl-hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-fluoro-benzoic acid N'-chloroacetyl-hydrazide(905118-28-7)
• EPA Substance Registry System: 3-fluoro-benzoic acid N'-chloroacetyl-hydrazide(905118-28-7)

Safety Data

• Hazardous Substances Data: 905118-28-7(Hazardous Substances Data)

Upstream product

• 499-55-8 3-fluoro-benzoic acid hydrazide 
• 79-04-9 chloroacetyl chloride 
• 455-38-9 3-fluorobenzoic acid 
• 451-02-5 ethyl 3-fluorobenzoate 

Downstream Products

• 350672-16-1 2-chloromethyl-5-(3-fluoro-phenyl)-[1,3,4]oxadiazole 

Relevant articles and documents

Synthesis and biological evaluation of honokiol derivatives bearing 3-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)oxazol-2(3h)-ones as potential viral entry inhibitors against sars-cov-2

The 2019 coronavirus disease (COVID-19) caused by SARS-CoV-2 virus infection has posed a serious danger to global health and the economy. However, SARS-CoV-2 medications that are specific and effective are still being developed. Honokiol is a bioactive component from Magnoliae officinalis Cortex with damp-drying effect. To develop new potent antiviral molecules, a series of novel honokiol analogues were synthesized by introducing various 3-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)oxazol-2(3H)-ones to its molecule. In a SARS-CoV-2 pseudovirus model, all honokiol derivatives were examined for their antiviral entry activities. As a result, 6a and 6p demonstrated antiviral entry effect with IC50 values of 29.23 and 9.82 μM, respectively. However, the parental honokiol had a very weak antiviral activity with an IC50 value more than 50 μM. A biolayer interfero-metry (BLI) binding assay and molecular docking study revealed that 6p binds to human ACE2 protein with higher binding affinity and lower binding energy than the parental honokiol. A competitive ELISA assay confirmed the inhibitory effect of 6p on SARS-CoV-2 spike RBD’s binding with ACE2. Importantly, 6a and 6p (TC50 > 100 μM) also had higher biological safety for host cells than honokiol (TC50 of 48.23 μM). This research may contribute to the discovery of potential viral entrance inhibitors for the SARS-CoV-2 virus, although 6p’s antiviral efficacy needs to be validated on SARS-CoV-2 viral strains in a biosafety level 3 facility.

Synthesis and antifeedant activity of new oxadiazolyl 3(2H)-pyridazinones

A total of 20 new compounds containing the oxadiazolyl 3(2H)-pyridazinone moiety were synthesized. The structures of all the compounds were confirmed by 1H NMR, IR, MS, and elemental analysis. Their insect antifeedant activities against Asiatic corn borer Ostrinia furnacalis (Guenee) were examined and compared with commercial azadirachtin. The compounds exhibited significant levels of activity. The feeding deterrency values of IIIa,j were 57% and 51% at 500 mg/kg concentration, respectively.