905291-66-9

Basic information

• Product Name: methyl (3R)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-3-hydroxybutanoate
• Synonyms: methyl (3R)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-3-hydroxybutanoate
• CAS NO: 905291-66-9
• Molecular Weight: 353.375
• Mol File: 905291-66-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl (3R)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-3-hydroxybutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (3R)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-3-hydroxybutanoate(905291-66-9)
• EPA Substance Registry System: methyl (3R)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-3-hydroxybutanoate(905291-66-9)

Safety Data

• Hazardous Substances Data: 905291-66-9(Hazardous Substances Data)

Upstream product

• 916971-31-8 (R)-methyl 4-amino-3-hydroxybutanoate 
• 42876-57-3 4-(1-benzofuran-2-yl)benzoyl chloride 
• 36078-98-5 4-(Benzofuran-2-yl)benzoic acid 
• 69976-44-9 ethyl 4-(1-benzofuran-2-yl)benzoate 
• 98437-24-2 benzofuran-2-boronic acid 
• 70681-41-3 (R)-dimethyl malate 
• 51934-41-9 4-iodobenzoic acid ethyl ester 
• 114819-45-3 (R)-methyl 3,4-dihydroxybutanoate 
• 116381-08-9 methyl (3R)-4-azido-3-hydroxybutanoate 
• 223429-10-5 methyl (3R)-3-hydroxy-4-{[(4-methylphenyl)sulfonyl]oxy}butanoate 

Downstream Products

• 905291-67-0 methyl (3R)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-3-(methoxymethoxy)butanoate 
• 223466-82-8 (3R)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-3-(methoxymethoxy)butanoic acid 
• 223466-79-3 (3R)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-3-hydroxybutanoic acid 

Relevant articles and documents

Design and synthesis of novel metalloproteinase inhibitors

A series of N-benzoyl 4-aminobutyric acid hydroxamate analogs were synthesized and evaluated as matrix metalloproteinase inhibitors. Synthetic work was focused on the chemical modification of the 4-aminobutyric acid part using easily available starting materials. As such, chemical modification was carried out using commercially available starting materials such as 4-aminobutyric acid, (+)- and (-)-malic acid, and d- and l-glutamic acid derivatives. Among the compounds tested, N-[4-(benzofuran-2-yl)benzoyl] 4-amino-4S-hydroxymethylbutyric acid hydroxamates derived from l-glutamic acid demonstrated more potent inhibitory activity against MMP-2 and MMP-9 compared with the corresponding 2S-hydroxy analogs or 3S-hydroxy analogs, respectively, which were derived from (-)-malic acid. Structure-activity relationship study is presented.