90633-29-7 Usage
Description
1-(2,2,2-trifluoroethyl)piperidin-4-ol is a chemical compound characterized by a piperidine ring with a fluorinated ethyl group. It is known for its potential applications in the pharmaceutical industry due to its unique chemical structure, which may possess therapeutic properties. The presence of the trifluoroethyl group also contributes to its distinct physical and chemical properties, making it a valuable compound for scientific and industrial research.
Uses
Used in Pharmaceutical Research:
1-(2,2,2-trifluoroethyl)piperidin-4-ol is used as an intermediate in organic synthesis and pharmaceutical research for its potential therapeutic properties. Its unique chemical structure allows for further exploration into the development of new pharmaceutical drugs.
Used in Organic Synthesis:
In the field of organic synthesis, 1-(2,2,2-trifluoroethyl)piperidin-4-ol serves as a valuable intermediate due to its distinct chemical properties. The trifluoroethyl group can influence the compound's reactivity and stability, making it a useful building block for the creation of more complex molecules.
Used in Scientific and Industrial Applications:
1-(2,2,2-trifluoroethyl)piperidin-4-ol's unique properties also make it valuable for various scientific and industrial purposes. Further research on the biological and chemical properties of 1-(2,2,2-trifluoroethyl)piperidin-4-ol could potentially lead to the discovery of new drugs or materials, expanding its applications in these fields.
Check Digit Verification of cas no
The CAS Registry Mumber 90633-29-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,0,6,3 and 3 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 90633-29:
(7*9)+(6*0)+(5*6)+(4*3)+(3*3)+(2*2)+(1*9)=127
127 % 10 = 7
So 90633-29-7 is a valid CAS Registry Number.
90633-29-7Relevant articles and documents
Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists
Lu, Hongfu,Yang, Ting,Xu, Zhongmiao,Lin, Xichen,Ding, Qian,Zhang, Yueting,Cai, Xin,Dong, Kelly,Gong, Sophie,Zhang, Wei,Patel, Metul,Copley, Royston C. B.,Xiang, Jianing,Guan, Xiaoming,Wren, Paul,Ren, Feng
supporting information, p. 2518 - 2532 (2018/03/26)
CXCR2 has emerged as a therapeutic target for not only peripheral inflammatory diseases but also neurological abnormalities in the central nervous system (CNS). Herein, we describe the discovery of a novel 1-cyclopentenyl-3-phenylurea series as potent and CNS penetrant CXCR2 antagonists. Extensive SAR studies, wherein molecules' property forecast index (PFI) was carefully optimized for overall balanced developability profiles, led to the discovery of the advanced lead compound 68 with a desirable PFI. Compound 68 demonstrated good in vitro pharmacology with excellent selectivity over CXCR1 and other chemokine receptors. Rat and dog pharmacokinetics (PK) revealed good oral bioavailability, high oral exposure, and desirable elimination half-life of the compound in both species. In addition, the compound demonstrated dose-dependent efficacy in the in vivo pharmacology neutrophil infiltration "air pouch" model in rodents after oral administration. Further, compound 68 is a CNS penetrant molecule with high unbound fraction in brain tissue.
1 -(CYCLOPENT-2-EN-1 -YL)-3-(2-HYDROXY-3-(ARYLSULFONYL)PHENYL)UREA DERIVATIVES AS CXCR2 INHIBITORS
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Page/Page column 112, (2015/12/18)
The invention relates to 1-(3-sulfonylphenyl)-3-(cyclopent-2-en-1-yl)urea derivatives, and their use in treating or preventing diseases and conditions mediated by the CXCR2 receptor. In addition, the invention relates to compositions containing the derivatives and processes for their preparation.
