91-61-2

Basic information

• Product Name: 6-METHYL-1,2,3,4-TETRAHYDROQUINOLINE
• Synonyms: P-METHYLTETRAHYDROQUINOLINE;QUINOLINE, 1,2,3,4-TETRAHYDRO-6-METHYL;TETRAHYDRO PARA METHYL QUINOLINE;1,2,3,4-tetrahydro-6-methyl-quinolin;Civettal;1,2,3,4-TETRAHYDRO-6-METHYLQUINOLINE;6-METHYL-1,2,3,4-TETRAHYDROQUINOLINE;AKOS B016030
• CAS NO: 91-61-2
• Molecular Formula: C₁₀H₁₃N
• Molecular Weight: 147.22
• EINECS: 202-083-0
• Mol File: 91-61-2.mol
• Article Data: 88

Chemical Properties

• Melting Point: 36-38°C
• Boiling Point: 262-263°C 712mm
• Flash Point: 262-263°C/712mm
• Appearance: /
• Density: 0.99g/cm³
• Vapor Pressure: 0.00982mmHg at 25°C
• Refractive Index: 1.539
• PKA: 5.69±0.20(Predicted)
• Water Solubility: Insoluble in water.
• BRN: 122515
• CAS DataBase Reference: 6-METHYL-1,2,3,4-TETRAHYDROQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-METHYL-1,2,3,4-TETRAHYDROQUINOLINE(91-61-2)
• EPA Substance Registry System: 6-METHYL-1,2,3,4-TETRAHYDROQUINOLINE(91-61-2)

Safety Data

• Statements: 20/21/22
• Safety Statements: 26-36/37/39
• TSCA: Yes
• Hazardous Substances Data: 91-61-2(Hazardous Substances Data)

Usage

Description

6-METHYL-1,2,3,4-TETRAHYDROQUINOLINE is a yellowish crystalline compound with a strong, civet-like odor. It is soluble in 2 parts of 80% alcohol and is combustible. 6-METHYL-1,2,3,4-TETRAHYDROQUINOLINE is primarily used as a pharmaceutical intermediate, playing a crucial role in the synthesis of various pharmaceuticals.

Uses

Used in Pharmaceutical Industry:
6-METHYL-1,2,3,4-TETRAHYDROQUINOLINE is used as a pharmaceutical intermediate for the synthesis of various drugs. Its unique chemical properties make it a valuable component in the development of new medications, contributing to the advancement of healthcare and treatment options.

InChI:InChI=1/C10H13N/c1-8-4-5-10-9(7-8)3-2-6-11-10/h4-5,7,11H,2-3,6H2,1H3

Upstream product

• 91-62-3 6-methylquinoline 
• 64-19-7 acetic acid 
• 67-63-0 isopropyl alcohol 
• 19342-88-2 3-chloro-N-(4-methylphenyl)propionamide 
• 20150-83-8 6-methyl-1,2,3,4-tetrahydroquinolin-2-one 
• 53279-82-6 (3-iodo-4-methoxyphenyl)methanol 
• 4113-04-6 quinoline-6-carbaldehyde 
• 34897-84-2 2-amino-5-methylbenzyl alcohol 
• 64-17-5 ethanol 
• 23395-72-4 quinoline-6-carbonitrile 
• 4053-42-3 6-methylquinoline-N-oxide 
• 15258-46-5 N-allyl-p-toluidine 
• 106-49-0 p-toluidine 
• 7647-01-0 hydrogenchloride 

Downstream Products

• 91-62-3 6-methylquinoline 
• 93817-07-3 1-benzoyl-6-methyl-1,2,3,4-tetrahydro-quinoline 
• 129247-22-9 N-(6-Methyl-3,4-dihydro-2H-quinolin-1-yl)-2-phenyl-acetamide 
• 660-68-4 diethyl amine hydrochloride 
• 104828-68-4 N,N-dimethyl-3-(3'-tolyl)propylamine 
• 861532-10-7 benzoic acid-[2-(3-chloro-propyl)-4-methyl-anilide] 
• 103661-41-2 C₁₁H₁₂ClNO 
• 1224638-85-0 [2-(3-chloro-4-fluoro-phenoxy)-pyridin-3-yl]-(6-methyl-3,4-dihydro-2H-quinolin-1-yl)-methanone 
• 1224638-39-4 [2-(2,5-dichloro-phenoxy)-pyridin-3-yl]-(6-methyl-3,4-dihydro-2H-quinolin-1-yl)-methanone 
• 1110272-51-9 2,4,6-Trichloro-N-[2-methyl-1-(6-methyl-3,4-dihydro-2H-quinolin-1-ylmethyl)propyl]benzenesulfonamide 
• 905196-07-8 C₁₇H₁₉NO₂S 
• 928743-69-5 1-tosyl-1,2,3,4-tetrahydroquinoline-6-carboxylic acid (2,4,6-mesityl)amide 
• 1163239-60-8 C₁₇H₁₇NO₄S 
• 1430561-32-2 (E)-4-(2-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(6-methyl-1,2,3,4-tetrahydroquinoline-1-carbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid 

Relevant articles and documents

Method for selective catalytic hydrogenation of aromatic heterocyclic compounds in non-hydrogen participation manner

The invention discloses a method for selective catalytic hydrogenation of aromatic heterocyclic compounds in a non-hydrogen participation manner. The method comprises the following steps: by taking 1, 5-cyclooctadiene iridium chloride dimer as a catalyst and phenylsilane as a hydrogen source, carrying out stirring reaction under mild conditions without adding a ligand, namely catalytically hydrogenating the aromatic heterocyclic compounds to obtain hydrogenated products of the aromatic heterocyclic compounds. The method has the advantages of low cost, mild reaction conditions, high selectivity and the like, and special equipment such as a high-pressure kettle and the like and high-temperature conditions which are required when hydrogen is used are avoided.

Heterogeneous Hydrogenation of Quinoline Derivatives Effected by a Granular Cobalt Catalyst

We communicate a convenient method for the pressure hydrogenation of quinolines in aqueous solution by using a particulate cobalt-based catalyst that is prepared in situ from simple Co(OAc)2 4H2O through reduction with abundant zinc powder. This catalytic protocol permits a brisk and atom-efficient access to a variety of 1,2,3,4-tetrahydroquinolines thereby relying solely on easy-to-handle reagents that are all readily obtained from commercial sources. Both the reaction setup assembly and the autoclave charging procedure are conducted on the bench outside an inert-gas-operated containment system, thus rendering the overall synthesis time-saving and operationally very simple.

Method for preparing tetrahydroquinoline compounds by catalytic hydrogenation of ruthenium catalyst

The invention relates to a method for preparing tetrahydroquinoline compounds by catalytic hydrogenation of a ruthenium catalyst, which comprises the following steps: by using p-cymene ruthenium chloride dimer as a catalyst and hydrogen as a reducing agent, mixing the p-cymene ruthenium chloride dimer, phosphine ligand and quinoline compounds, and dissolving the mixture in an organic solvent to react, and carrying out post-treatment to obtain the tetrahydroquinoline derivative. Compared with the prior art, the method has the advantages of easily available raw materials, mild conditions, simpleoperation, atom economy, simple and green synthesis process, mild reaction conditions, excellent selectivity, high yield and good reaction universality, and has a wide application value in fine chemical intermediate synthesis.