91-84-9

Basic information

• Product Name: PYRILAMINE
• Synonyms: 1,2-Ethanediamine, N-[(4-methoxyphenyl)methyl]-N',N'-dimethyl-N-2-pyridinyl-;1,2-Ethanediamine, N-[(4-methoxyphenyl)methyl]-N',N'-dimethyl-N-2-pyridyl-;2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)-pyridin;2-((2-(dimethylamino)ethyl)-(p-methoxybenzyl)amino)pyridine;2-((2-dimethylaminoethyl)(p-methoxybenzyl)amino)pyridine;2-((p-Methoxybenzyl)(2-(dimethylamino)ethyl)amino)pyridine;2-[[2-(Dimethylamino)ethyl](p-methoxybenzyl)amino]pyridine;Afko-Hist
• CAS NO: 91-84-9
• Molecular Formula: C₁₇H₂₃N₃O
• Molecular Weight: 285.38
• EINECS: 202-102-2
• Mol File: 91-84-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: bp5 201°; bp0.06 168-172°
• Appearance: /
• Density: 1.0141 (rough estimate)
• Refractive Index: nD25 1.5760-1.5765
• PKA: pKa 4.02(H2O t=25 c=0.002 to 0.01) (Uncertain);8.92 (Uncertain)
• Water Solubility: 3.425g/L(37.5 oC)
• CAS DataBase Reference: PYRILAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: PYRILAMINE(91-84-9)
• EPA Substance Registry System: PYRILAMINE(91-84-9)

Safety Data

• Hazardous Substances Data: 91-84-9(Hazardous Substances Data)

Usage

Description

PYRILAMINE, also known as N1-(4-Methoxybenzyl)-N2,N2-dimethyl-N1-(pyridin-2-yl)ethane-1,2-diamine, is an antihistamine drug that exhibits potent antihistaminic properties. It is commonly used for the treatment of various allergic conditions and symptoms.

Uses

Used in Pharmaceutical Industry:
PYRILAMINE is used as an antihistaminic agent for the treatment of allergy symptoms and rhinitis. It works by blocking the action of histamine, a chemical released during an allergic reaction, thereby providing relief from allergy symptoms.
Used in Pain Management:
PYRILAMINE is used in synergism with diclofenac as a therapeutic alternative for the clinical management of inflammatory pain. The combination of PYRILAMINE and diclofenac helps in reducing inflammation and pain associated with various conditions.

Synthesis Reference(s)

Journal of the American Chemical Society, 68, p. 1999, 1946 DOI: 10.1021/ja01214a037

Air & Water Reactions

May be sensitive to light. Insoluble in water.

Reactivity Profile

PYRILAMINE neutralizes acids to form salts plus water in exothermic reactions. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate flammable gaseous hydrogen in combination with strong reducing agents, such as hydrides.

Health Hazard

SYMPTOMS: Exposure to PYRILAMINE may cause somnolence, central nervous system depression and gastrointestinal disturbances. It may also cause drowsiness, dryness of the mouth, headache, nausea, tachycardia, urinary retention, nervousness, disorientation, staggering gait, hallucinations, stupor, coma, hyperflexia, tremors, excitement, nystagmus, hyperthermia, convulsions, agranulocytosis and aplastic anemia.

Fire Hazard

Flash point data for PYRILAMINE are not available; however, PYRILAMINE is probably combustible.

InChI:InChI=1/C17H23N3O/c1-19(2)12-13-20(17-6-4-5-11-18-17)14-15-7-9-16(21-3)10-8-15/h4-11H,12-14H2,1-3H3

Upstream product

• 107-99-3 2-(dimethylamino)ethyl chloride 
• 2746-25-0 p-Methoxybenzyl bromide 
• 824-94-2 p-methoxybenzyl chloride 
• 23826-72-4 N,N-dimethyl-N'-(pyridine-2-yl)ethane-1,2-diamine 
• 105-13-5 4-Methoxybenzyl alcohol 
• 109-09-1 2-chloropyridine 
• 65875-39-0 N¹-(4-methoxybenzyl)-N²,N²-dimethylethane-1,2-diamine 

Downstream Products

• 98982-99-1 N'-(4-methoxy-benzyl)-N,N-dimethyl-N'-[2]pyridyl-ethylenediamine-N-oxide 
• 145823-19-4 ((2R,3R,4S,5S,6S)-6-Carboxy-3,4,5-trihydroxy-tetrahydro-pyran-2-yl)-{2-[(4-methoxy-benzyl)-pyridin-2-yl-amino]-ethyl}-dimethyl-ammonium; chloride 
• 104499-47-0 N-Desmethylpyrilamine 
• 1345012-51-2 (5-(1-((2-((4-methoxybenzyl)(pyridin-2-yl)amino)ethyl)(methyl)amino)propan-2-ylamino)-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone 
• 1345012-50-1 1-((2-((4-methoxybenzyl)(pyridin-2-yl)amino)ethyl)(methyl)amino)propan-2-one 
• 1345012-42-1 (5-chloro-1H-indol-2-yl)(4-(2-((2-((4-methoxybenzyl)(pyridin-2-yl)amino)ethyl)(methyl)amino)ethyl)piperazin-1-yl)methanone 
• 1345012-41-0 (1H-indol-2-yl)(4-(2-((2-((4-methoxybenzyl)(pyridin-2-yl)amino)ethyl)(methyl)amino)ethyl)piperazin-1-yl)methanone 
• 1345012-37-4 tert-butyl 4-(2-((2-((4-methoxybenzyl)(pyridin-2-yl)amino)ethyl)(methyl)amino)ethyl)piperazine-1-carboxylate 

Relevant articles and documents

Photoredox-catalyzed decarboxylative cross-coupling of α-amino acids with nitrones

A decarboxylative cross-coupling reaction of α-amino acids with nitrones via visible-light-induced photoredox catalysis has been established for easy access to β-amino hydroxylamines and vicinal diamines with structural diversity, which is featured with simple operation, mild conditions, readily available α-amino acids, and a broad scope of nitrone substrates. The application of this protocol can furnish efficient synthetic strategies for some valuable vicinal diamine-containing molecules.