910-99-6 Usage
Description
17,21-Dihydroxy-16beta-methylpregna-1,4,9(11)-triene-3,20-dione 21-acetate is a synthetic corticosteroid and a derivative of cortisol. It is characterized by its potent anti-inflammatory and immunosuppressive properties, which are achieved by inhibiting the release of inflammatory cytokines and suppressing the activity of immune cells. The addition of the acetate group to its structure enhances its stability and prolongs its duration of action in the body.
Uses
Used in Pharmaceutical Industry:
17,21-Dihydroxy-16beta-methylpregna-1,4,9(11)-triene-3,20-dione 21-acetate is used as an anti-inflammatory and immunosuppressive agent for the treatment of various inflammatory and autoimmune conditions. Its applications include the management of skin conditions, asthma, allergic reactions, rheumatoid arthritis, lupus, and inflammatory bowel disease.
Used in Topical Treatments:
In the form of creams and ointments, 17,21-dihydroxy-16beta-methylpregna-1,4,9(11)-triene-3,20-dione 21-acetate is used for localized treatment of skin conditions. Its potent anti-inflammatory action helps alleviate symptoms such as redness, swelling, and itching.
Used in Respiratory Treatments:
As an ingredient in inhalers, 17,21-dihydroxy-16beta-methylpregna-1,4,9(11)-triene-3,20-dione 21-acetate is used to treat asthma and other respiratory conditions. It helps reduce inflammation in the airways, improving breathing and reducing the frequency of asthma attacks.
Used in Systemic Treatments:
In oral or injectable formulations, 17,21-dihydroxy-16beta-methylpregna-1,4,9(11)-triene-3,20-dione 21-acetate is used for systemic conditions such as rheumatoid arthritis, lupus, and inflammatory bowel disease. Its immunosuppressive properties help control the immune system's overactivity and reduce inflammation throughout the body.
Check Digit Verification of cas no
The CAS Registry Mumber 910-99-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 9,1 and 0 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 910-99:
(5*9)+(4*1)+(3*0)+(2*9)+(1*9)=76
76 % 10 = 6
So 910-99-6 is a valid CAS Registry Number.
InChI:InChI=1/C24H30O5/c1-14-11-20-18-6-5-16-12-17(26)7-9-22(16,3)19(18)8-10-23(20,4)24(14,28)21(27)13-29-15(2)25/h7-9,12,14,18,20,28H,5-6,10-11,13H2,1-4H3/t14-,18+,20-,22-,23-,24-/m0/s1
910-99-6Relevant articles and documents
Preparation method of betamethasone epoxide
-
Paragraph 0098; 0099; 0115; 0116; 0122; 0123; 0129; 0130, (2020/12/15)
The invention provides a preparation method of a betamethasone epoxide, which comprises the steps of step 1, preparing a first reaction solution containing a compound II by using a compound I based onan esterification reaction; step 2, based on a bromine hydroxylation reaction, preparing a second reaction solution containing a compound III by using the first reaction solution; and 3, based on a hydrolysis reaction, preparing a betamethasone epoxide IV crude product by using the second reaction solution. The betamethasone epoxide IV is synthesized from the compound I by adopting a one-pot method, the method has the advantages of high yield, simplicity and safety in operation, low cost, small pollution and the like, and the method is stable and easy to realize industrial production.
Betamethasone intermediates or its preparation method of the analogue
-
, (2016/12/22)
The invention relates to a preparation method of a steroid hormone medicinal intermediate, in particular to a preparation method for a betamethasone intermediate or its analogue. The betamethasone intermediate or its analogue is prepared from a compound I by means of elimination reaction, methylation reaction, cyano-group substitution reaction, siloxy protective reaction, intramolecular nucleophilic substitution reaction and esterification reaction. The method provided by the invention has the characteristics of cheap raw materials, and high and stable yield. The reaction route is as the following, wherein R1 is Cl or Br, and R is H or hydrocarbonyl of C1-C10.
NON-HORMONAL STEROID MODULATORS OF NF-KB FOR TREATMENT OF DISEASE
-
Paragraph 0165; 0166, (2015/09/23)
The present invention relates to compounds and methods which may be useful as treatments of neuromuscular diseases such as muscular dystrophy, and as inhibitors of NF-κB for the treatment or prevention of muscular wasting disease, including muscular dystrophy.
