911-40-0 Usage
Description
7-Ketodeoxycholic Acid, also known as 7-Keto-3α,12-α-dihydroxycholanic Acid, is a chemical compound with the CAS number 911-40-0. It is a derivative of cholic acid, a bile acid that plays a crucial role in the digestion and absorption of dietary fats. 7-KETODEOXYCHOLIC ACID is characterized by the presence of a ketone group at the 7th position and hydroxyl groups at the 3α and 12α positions. Its unique structure and properties make it a valuable compound for various applications in organic synthesis.
Uses
Used in Organic Synthesis:
7-Ketodeoxycholic Acid is used as a key intermediate in the synthesis of various organic compounds. Its unique structure allows for the formation of new chemical bonds and the modification of existing ones, making it a versatile building block for the development of new molecules with potential applications in various industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 7-Ketodeoxycholic Acid is used as a starting material for the synthesis of drug candidates. Its ability to form new chemical entities makes it a valuable asset in the development of novel therapeutic agents with improved efficacy and reduced side effects.
Used in Chemical Research:
7-Ketodeoxycholic Acid is also used in chemical research to study the properties and reactivity of bile acids and their derivatives. This knowledge can contribute to a better understanding of the role of bile acids in various biological processes and the development of new strategies for the treatment of related disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 911-40-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 9,1 and 1 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 911-40:
(5*9)+(4*1)+(3*1)+(2*4)+(1*0)=60
60 % 10 = 0
So 911-40-0 is a valid CAS Registry Number.
InChI:InChI=1/C24H38O5/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26/h13-18,20,22,25,27H,4-12H2,1-3H3,(H,28,29)/t13-,14+,15-,16-,17+,18+,20+,22+,23+,24-/m1/s1
911-40-0Relevant articles and documents
Keller,Weiss
, p. 25 (1951)
SYNTHETIC DERIVATIVES OF CHOLIC ACID 7-SULFATE AND USES THEREOF
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Paragraph 00332-00333, (2020/07/05)
The compositions and methods provided herein are related, in part, to the discovery of cholic acid 7-sulfate as a treatment for diabetes. Provided herein is a method for treating a metabolic disorder (e.g., diabetes, obesity), or an inflammatory disease (e.g., Crohn's disease, inflammatory bowel disease, ulcerative colitis, pancreatitis, hepatitis, appendicitis, gastritis, diverticulitis, celiac disease, food intolerance, enteritis, ulcer, gastroesophageal reflux disease (GERD), psoriatic arthritis, psoriasis, and rheumatoid arthritis) in a subject in need thereof comprising administering to a subject a compound of Formulae (I)-(XVII).
NAD+-Dependent Enzymatic Route for the Epimerization of Hydroxysteroids
Tonin, Fabio,Otten, Linda G.,Arends, Isabel W. C. E.
, p. 3192 - 3203 (2018/11/10)
Epimerization of cholic and chenodeoxycholic acid (CA and CDCA, respectively) is a notable conversion for the production of ursodeoxycholic acid (UDCA). Two enantiocomplementary hydroxysteroid dehydrogenases (7α- and 7β-HSDHs) can carry out this transformation fully selectively by specific oxidation of the 7α-OH group of the substrate and subsequent reduction of the keto intermediate to the final product (7β-OH). With a view to developing robust and active biocatalysts, novel NADH-active 7β-HSDH species are necessary to enable a solely NAD+-dependent redox-neutral cascade for UDCA production. A wild-type NADH-dependent 7β-HSDH from Lactobacillus spicheri (Ls7β-HSDH) was identified, recombinantly expressed, purified, and biochemically characterized. Using this novel NAD+-dependent 7β-HSDH enzyme in combination with 7α-HSDH from Stenotrophomonas maltophilia permitted the biotransformations of CA and CDCA in the presence of catalytic amounts of NAD+, resulting in high yields (>90 %) of UCA and UDCA.
