913-04-2

Basic information

• Product Name: BZ-DL-ARG-BETANA HCL
• Synonyms: N-BENZOYL-DL-ARG-BETA-NAPHTHYLAMIDE HCL;N-BENZOYL-DL-ARGININE-B-NAPHTHYLAMIDE HYDROCHLORIDE;N-ALPHA-BENZOYL-DL-ARG-BETA-NAPHTHYLAMIDE HCL;N-ALPHA-BENZOYL-DL-ARGININE-2-NAPHTHYLAMIDE HYDROCHLORIDE;N-ALPHA-BENZOYL-DL-ARGININE BETA-NAPHTHYLAMIDE HYDROCHLORIDE;DL-BANA;BZ-DL-ARG-BETANA HCL;BZ-DL-ARGININE-BETANA HCL
• CAS NO: 913-04-2
• Molecular Formula: C23H26ClN5O2
• Molecular Weight: 439.94
• EINECS: 213-015-4
• Product Categories: Amino Acids
• Mol File: 913-04-2.mol
• Article Data: 0

Chemical Properties

• Melting Point: 196-199 °C
• Appearance: /
• Storage Temp.: 2-8°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• BRN: 3823291
• CAS DataBase Reference: BZ-DL-ARG-BETANA HCL(CAS DataBase Reference)
• NIST Chemistry Reference: BZ-DL-ARG-BETANA HCL(913-04-2)
• EPA Substance Registry System: BZ-DL-ARG-BETANA HCL(913-04-2)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• F: 10-21
• Hazardous Substances Data: 913-04-2(Hazardous Substances Data)

Usage

Description

BZ-DL-ARG-BETANA HCL, also known as Nα-Benzoyl-DL-arginine β-naphthylamide hydrochloride, is a synthetic substrate commonly used in biochemical assays to evaluate the activity of proteolytic enzymes, particularly trypsin and its inhibitors.
Used in Biochemical Research:
BZ-DL-ARG-BETANA HCL is used as a substrate in the BANA test for evaluating the inhibitory activity of stefin, a cysteine protease inhibitor. This application aids researchers in understanding the interactions between proteases and their inhibitors, which is crucial for studying various biological processes and potential therapeutic targets.
Used in Enzyme Inhibition Studies:
In the field of enzyme kinetics, BZ-DL-ARG-BETANA HCL serves as a substrate for determining the Ki values of inhibitors toward trypsin. Ki is a measure of the inhibitor's affinity for the enzyme and is essential for assessing the potency and selectivity of potential drugs targeting trypsin-mediated pathways. This application is vital for drug discovery and the development of therapeutic agents that modulate trypsin activity.

Biochem/physiol Actions

Nα-Benzoyl-DL-arginine β-naphthylamide hydrochloride (BANA) helps to determine the activities of cathepsin B and papain. BANA test is also useful in identifying the number of periodontal sites with periodontal pathogens. Presence of volatile sulfur compounds (VSCs), synthesized by oral bacteria in dental plaque or tongue coating can be colorimetrically confirmed by their ability to hydrolyze N-benzoyl-DL-arginine-2-naphthylamide.

InChI:InChI=1/C23H25N5O2.ClH/c24-23(25)26-14-6-11-20(28-21(29)17-8-2-1-3-9-17)22(30)27-19-13-12-16-7-4-5-10-18(16)15-19;/h1-5,7-10,12-13,15,20H,6,11,14H2,(H,27,30)(H,28,29)(H4,24,25,26);1H