913002-87-6

Basic information

• Product Name: 1H-Indazol-4-amine, 1-(4-fluorophenyl)-
• Synonyms: 1-(4-fluorophenyl)indazol-4-amine;1-(4-fluorophenyl)-1H-indazol-4-amine;4-amino-1-(4-fluorophenyl)indazole
• CAS NO: 913002-87-6
• Molecular Formula: C13H10FN3
• Molecular Weight: 227.241
• Mol File: 913002-87-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 341.2±38.0 °C(Predicted)
• Density: 1.32±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 1H-Indazol-4-amine, 1-(4-fluorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indazol-4-amine, 1-(4-fluorophenyl)-(913002-87-6)
• EPA Substance Registry System: 1H-Indazol-4-amine, 1-(4-fluorophenyl)-(913002-87-6)

Safety Data

• Hazardous Substances Data: 913002-87-6(Hazardous Substances Data)

Upstream product

• 934987-79-8 1-(4-fluorophenyl)-4-nitroindazole 
• 352-34-1 4-fluoro-1-iodobenzene 
• 41748-71-4 4-aminoindazole 
• 606-31-5 2,6-dinitrobenzaldehyde 
• 823-85-8 4-fluorophenyhydrazine hydrochloride 

Downstream Products

• 934987-80-1 N-[2-[[1-(4-fluorophenyl)indazol-4-yl]amino]-2-methylpropyl]benzamide 
• 1021536-91-3 4-(3-fluoro-2-methoxyphenyl)-1,1,1-trifluoro-2-{[(4-fluorophenyl)indazol-4-yl]iminomethyl}-4-methyl-pentan-2-ol 
• 1023287-51-5 (2R)-4-(3-fluoro-2-methoxyphenyl)-1,1,1-trifluoro-2-{[(4-fluorophenyl)indazol-4-yl]iminomethyl}hexan-2-ol 

Relevant articles and documents

Highly tractable, sub-nanomolar non-steroidal glucocorticoid receptor agonists

Starting from a non-steroidal glucocorticoid agonist aryl pyrazole derivative, the NFκB agonist activity was optimised in an iterative process from pIC50 7.5 (for 7), to pIC50 10.1 (for 38E1). An explanation for the SAR observed base

Indazole and indole derivatives as anti-inflammatory agents

The present invention relates to the compounds of formula I, processes for their production and their use as anti-inflammatory agents.

NOVEL COMPOUNDS

The present invention provides glucocorticoid receptor agonists of formula (I), a process for their preparation, pharmaceutical compositions comprising the compounds and the preparation of said compositions, intermediates and use of the compounds for the