91619-31-7

Basic information

• Product Name: 1-(3-NITROPHENYLSULFONYL)PIPERIDINE
• Synonyms: AURORA 22087;1-(3-NITROPHENYLSULFONYL)PIPERIDINE;1-(3-Nitro-benzenesulfonyl)-piperidine;BAS 00116566;NSC175845;ST065443;ZINC03848627
• CAS NO: 91619-31-7
• Molecular Formula: C₁₁H₁₄N₂O₄S
• Molecular Weight: 270.3
• Product Categories: blocks;NitroCompounds;Sulfonamides
• Mol File: 91619-31-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 429.1 °C at 760 mmHg
• Flash Point: 213.3 °C
• Appearance: /
• Density: 1.374 g/cm³
• Vapor Pressure: 1.44E-07mmHg at 25°C
• Refractive Index: 1.592
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(3-NITROPHENYLSULFONYL)PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-NITROPHENYLSULFONYL)PIPERIDINE(91619-31-7)
• EPA Substance Registry System: 1-(3-NITROPHENYLSULFONYL)PIPERIDINE(91619-31-7)

Safety Data

• Hazardous Substances Data: 91619-31-7(Hazardous Substances Data)

Usage

General Description

1-(3-Nitrophenylsulfonyl)piperidine is a chemical compound that belongs to the class of sulfonamides. It is a piperidine derivative with a nitrophenylsulfonyl functional group attached to the piperidine ring. 1-(3-NITROPHENYLSULFONYL)PIPERIDINE is often used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It has been studied for its potential as a non-peptide angiotensin receptor antagonist and has shown promising results in inhibiting the activity of certain enzymes. Additionally, it has been investigated for its potential use as a reagent in organic chemistry reactions and as a molecular probe in biological studies. Overall, 1-(3-nitrophenylsulfonyl)piperidine is a versatile compound with diverse potential applications in the fields of medicine, agriculture, and chemical research.

InChI:InChI=1/C11H14N2O4S/c14-13(15)10-5-4-6-11(9-10)18(16,17)12-7-2-1-3-8-12/h4-6,9H,1-3,7-8H2

Upstream product

• 110-89-4 piperidine 
• 98634-21-0 4-nitrophenyl 3-nitrobenzenesulfonate 
• 121-51-7 3-nitrobenzenesulphonyl chloride 
• 84752-61-4 pyridinium paratoluene sulfonic acid 
• 857784-71-5 3-nitro-N,N-bis-(3-nitro-benzenesulfonyl)-aniline 

Downstream Products

• 22184-99-2 3-(piperidine-1-sulfonyl)-phenylamine 

Relevant articles and documents

FLT3 RECEPTOR ANTAGONISTS

The invention pertains to novel FLT3receptor antagonists of general formula (1). The compounds are useful for the treatment or the prevention of pain disorders, cancer and autoimmune diseases.

Synthesis and anticandidal activity of azole-containing sulfonamides

Twenty five benzenesulfonamides containing one imidazole or triazole ring, or two imidazole or triazole rings have been synthesized and evaluated as anticandidal agents. The most active compounds were 5c, 6b, 6c, 6e, and 17b, which exhibited MIC values of 4.55-24.39 mM depending on the clinical isolate. Comparing imidazole to triazole derivatives did not show a clear effect on activity. Compounds containing a N-benzyl group also showed no clear evidence on activity given the fact that they have an extra aromatic ring. Secondary sulfonamides, 5l, 5m, and 5n showed activities that were proportional to their lipophilicity. The activities of N-aryl-substituted derivatives 5j, 5k, 5l, 5m, 5n, and 6j were also proportional to their lipophilicity. Halogenation enhanced the activity as a result of improvement of lipophilicity. The presence of two imidazole or triazole rings in the same compound did not show a clear enhancement of activity.

Direct Synthesis of Sulfonamides and Activated Sulfonate Esters from Sulfonic Acids

A general new method for the preparation of sulfonamides and activated sulfonate esters by the direct coupling of sulfonic acid salts with amines and alcohols using the reagent triphenylphosphine ditriflate is described. A new reusable polymer-supported reagent for these transformations under heterogeneous conditions is also described. These methods provide a fundamentally new approach to making small molecules containing the sulfonamide functional group. Copyright