91797-84-1

Basic information

• Product Name: 2,2-Dimethyl-N-[(1R)-1-Phenylethyl]Propanamide
• Synonyms: 2,2-Dimethyl-N-[(1R)-1-Phenylethyl]Propanamide;(R)-N-(1-phenylethyl)pivalamide
• CAS NO: 91797-84-1
• Molecular Formula: C₁₃H₁₉NO
• Molecular Weight: 205.29606
• Mol File: 91797-84-1.mol
• Article Data: 11

Chemical Properties

• Melting Point: 119-119.5 °C(Solv: hexane (110-54-3))
• Boiling Point: 353.0±21.0 °C(Predicted)
• Appearance: /
• Density: 0.970±0.06 g/cm3(Predicted)
• PKA: 15?+-.0.46(Predicted)
• CAS DataBase Reference: 2,2-Dimethyl-N-[(1R)-1-Phenylethyl]Propanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-Dimethyl-N-[(1R)-1-Phenylethyl]Propanamide(91797-84-1)
• EPA Substance Registry System: 2,2-Dimethyl-N-[(1R)-1-Phenylethyl]Propanamide(91797-84-1)

Safety Data

• Hazardous Substances Data: 91797-84-1(Hazardous Substances Data)

Usage

General Description

2,2-Dimethyl-N-[(1R)-1-Phenylethyl]Propanamide is a chemical compound that belongs to the class of amides. It is a white or off-white crystalline solid at room temperature. 2,2-Dimethyl-N-[(1R)-1-Phenylethyl]Propanamide is also known by its common name, 2,2-Dimethyl-2-Phenylpropanamide. It is used in the synthesis of various pharmaceuticals and organic compounds. This chemical has a molecular formula of C13H19NO and a molecular weight of 205.29 g/mol. It is important to handle this chemical with care, as it may pose some health risks if not properly handled and disposed of.

Upstream product

• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 630-19-3 pivalaldehyde 
• 64528-63-8 N-(1-phenylethyl)pivalamide 
• 75-98-9 Trimethylacetic acid 
• 3282-30-2 pivaloyl chloride 

Downstream Products

• 131615-22-0 (3R)-3-Methyl-2,3-dihydro-1H-isoindol-1-one 
• 183204-10-6 2,2-Dimethyl-N-{(R)-1-[2-(2-oxo-propane-1-sulfonyl)-phenyl]-ethyl}-propionamide 
• 183204-11-7 2,2-Dimethyl-N-{(R)-1-[2-(2-oxo-2-phenyl-ethanesulfonyl)-phenyl]-ethyl}-propionamide 
• 139223-53-3 2,2-Dimethyl-N-{(R)-1-[2-((S)-phenylmethanesulfinyl)-phenyl]-ethyl}-propionamide 
• 139223-52-2 N-{(R)-1-[2-((S)-Butane-1-sulfinyl)-phenyl]-ethyl}-2,2-dimethyl-propionamide 
• 144434-06-0 (2S,3S)-2-{(S)-2-[(R)-1-(2,2-Dimethyl-propionylamino)-ethyl]-benzenesulfinyl}-3-hydroxy-3-(4-nitro-phenyl)-propionic acid tert-butyl ester 
• 144434-07-1 (2S,3S)-2-{(S)-2-[(R)-1-(2,2-Dimethyl-propionylamino)-ethyl]-benzenesulfinyl}-3-hydroxy-3-(2-nitro-phenyl)-propionic acid tert-butyl ester 
• 144434-04-8 (2S,3S)-2-{(S)-2-[(R)-1-(2,2-Dimethyl-propionylamino)-ethyl]-benzenesulfinyl}-3-hydroxy-3-(3-methoxy-phenyl)-propionic acid tert-butyl ester 
• 144434-03-7 (2S,3S)-2-{(S)-2-[(R)-1-(2,2-Dimethyl-propionylamino)-ethyl]-benzenesulfinyl}-3-hydroxy-3-(4-methoxy-phenyl)-propionic acid tert-butyl ester 

Relevant articles and documents

Rhodium-Catalyzed oxidative amidation of sterically hindered aldehydes and alcohols

A rhodium-catalyzed oxidative amidation reaction has been developed with sterically hindered aldehydes and alcohols for the synthesis of amides containing a quaternary carbon at the α position. A variety of amine nucleophiles, both aliphatic and aromatic, are employed and afford the corresponding amides in good to excellent yields. Finally, mechanistic studies are performed to gain insight into both catalytic cycles.

NEW CHIRAL STATIONARY PHASES FOR CHROMATOGRAPHY BASED ON AROMATIC ALLYL AMINES

New chiral stationary phases (CSPs) based on chiral selectors covalently bound on a solid support were prepared. Chiral selectors were obtained from enantiomerically pure aromatic amines and 3,5-dinitrobenzoic acid and then linked to the support surface through the allylic double bond. Such obtained materials allow enantioseparation of racemates or enantiomerically enriched compounds. These chiral stationary phases can be used as fillings in chromatographic columns for enantiomer separation of naproxen type drugs and other similar non-steroidal anti-inflammatory drugs (NSAID) by means of high performance liquid chromatography on both the analytical and preparative scale.

Processes for producing 7-isoindolinequinolonecarboxylic derivatives and intermediates therefor, salts of 7-isoindolinequinolonecarboxylic acids, hydrates thereof, and composition containing the same as active ingredient

This invention relates to processes for producing a 7-isoindoline-quinolonecarboxylic acid derivative represented by the general formula [1] which is useful as an antibacterial agent, and an intermediate thereof: wherein R1represents a hydrogen atom or a carboxyl-protecting group; R2represents a substituted or unsubstituted alkyl, alkenyl, cycloalkyl, aryl or heterocyclic group; R3represents at least one group selected from hydrogen atom, halogen atoms, substituted or unsubstituted alkyl, alkenyl, cycloalkyl, aryl, alkoxy or alkylthio groups, nitro group, cyano group, acyl groups, protected or unprotected hydroxyl groups and protected or unprotected or substituted or unsubstituted amino groups; R4represents at least one group selected from hydrogen atom, halogen atoms, substituted or unsubstituted alkyl, alkenyl, cycloalkyl, aralkyl, aryl, alkoxy or alkylthio groups, protected or unprotected hydroxyl or imino groups, protected or unprotected or substituted or unsubstituted amino groups, alkylidene groups, oxo group and groups each forming a cycloalkane group together with the carbon atom to which R4bonds; R5represents a hydrogen atom, an amino-protecting group, a substituted or unsubstituted alkyl, cycloalkyl, alkylsulfonyl, arylsulfonyl, acyl or aryl group; R6represents a hydrogen atom, a halogen atom, a substituted or unsubstituted alkyl, alkoxy or alkylthio group, a protected or unprotected hydroxyl or amino group or a nitro group; and A represents CH or C—R7in which R7represents a halogen atom, a substituted or unsubstituted alkyl, alkoxy or alkylthio group or a protected or unprotected hydroxyl group, and to a salt of a 7-isoindoline-quinolonecarboxylic acid represented by the general formula [1], a hydrate thereof and a composition comprising them as an active ingredient.