919109-90-3Relevant articles and documents
Identification of a nonbasic, nitrile-containing cathepsin K inhibitor (MK-1256) that is efficacious in a monkey model of osteoporosis
Robichaud, J?el,Black, W. Cameron,Thérien, Michel,Paquet, Julie,Oballa, Renata M.,Bayly, Christopher I.,McKay, Daniel J.,Wang, Qingping,Isabel, Elise,Léger, Serge,Mellon, Christophe,Kimmel, Donald B.,Wesolowski, Gregg,Percival, M. David,Massé, Frédéric,Desmarais, Sylvie,Falgueyret, Jean-Pierre,Crane, Sheldon N.
experimental part, p. 6410 - 6420 (2009/10/23)
Herein, we report on the identification of nonbasic, potent, and highly selective, nitrile-containing cathepsin K (Cat K) inhibitors that are built on our previously identified cyclohexanecarboxamide core structure. Subsequent to our initial investigation