920509-13-3 Usage
Description
(3-chloro-4-hydroxy-5-methylphenyl)acetic acid, a chemical compound with the molecular formula C9H9ClO3, is a derivative of acetic acid featuring a hydroxyl group, a methyl group, and a chlorine atom attached to a phenyl ring. This versatile compound serves as a valuable intermediate in the synthesis of pharmaceuticals and agrochemicals, and it can also be utilized as a building block in organic synthesis for creating more complex molecules.
Uses
Used in Pharmaceutical Synthesis:
(3-chloro-4-hydroxy-5-methylphenyl)acetic acid is used as an intermediate in the pharmaceutical industry for the synthesis of various drugs. Its unique structure allows for the development of new medicinal compounds with potential therapeutic applications.
Used in Agrochemical Production:
In the agrochemical industry, (3-chloro-4-hydroxy-5-methylphenyl)acetic acid is employed as a starting material for the production of crop protection products. Its chemical properties make it suitable for the creation of effective agents to protect crops from pests and diseases.
Used in Organic Synthesis:
(3-chloro-4-hydroxy-5-methylphenyl)acetic acid is used as a building block in organic synthesis, allowing chemists to construct more complex molecules with diverse applications in various industries, including the development of new materials and compounds with specific properties.
Used in Drug Development:
(3-chloro-4-hydroxy-5-methylphenyl)acetic acid has potential applications in the development of new drugs, thanks to its unique structure and reactivity. Researchers can leverage its properties to design and synthesize novel pharmaceuticals with improved efficacy and selectivity for various medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 920509-13-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,2,0,5,0 and 9 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 920509-13:
(8*9)+(7*2)+(6*0)+(5*5)+(4*0)+(3*9)+(2*1)+(1*3)=143
143 % 10 = 3
So 920509-13-3 is a valid CAS Registry Number.
920509-13-3Relevant articles and documents
Discovery of 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3- yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a highly selective thyroid hormone receptor β agonist in clinical trials for the treatment of dyslipidemia
Kelly, Martha J.,Pietranico-Cole, Sherrie,Larigan, J. Douglas,Haynes, Nancy-Ellen,Reynolds, Charles H.,Scott, Nathan,Vermeulen, John,Dvorozniak, Mark,Conde-Knape, Karin,Huang, Kuo-Sen,So, Sung-Sau,Thakkar, Kshitij,Qian, Yimin,Banner, Bruce,Mennona, Frank,Danzi, Sara,Klein, Irwin,Taub, Rebecca,Tilley, Jefferson
, p. 3912 - 3923 (2014/06/09)
The beneficial effects of thyroid hormone (TH) on lipid levels are primarily due to its action at the thyroid hormone receptor β (THR-β) in the liver, while adverse effects, including cardiac effects, are mediated by thyroid hormone receptor α (THR-α). A pyridazinone series has been identified that is significantly more THR-β selective than earlier analogues. Optimization of this series by the addition of a cyanoazauracil substituent improved both the potency and selectivity and led to MGL-3196 (53), which is 28-fold selective for THR-β over THR-α in a functional assay. Compound 53 showed outstanding safety in a rat heart model and was efficacious in a preclinical model at doses that showed no impact on the central thyroid axis. In reported studies in healthy volunteers, 53 exhibited an excellent safety profile and decreased LDL cholesterol (LDL-C) and triglycerides (TG) at once daily oral doses of 50 mg or higher given for 2 weeks.
