921927-93-7 Usage
Description
4-Thiazolecarboxylic acid, 2-[(1R,3R)-3-[[(2S,3S)-2-azido-3-methyl-1-oxopentyl]amino]-1-hydroxy-4-methylpentyl]-, methyl ester is a complex organic compound that serves as an intermediate in the synthesis of Tubulysin and its impurities. This molecule is characterized by its unique structure, which includes a thiazolecarboxylic acid core, a methyl ester group, and a series of chiral centers that contribute to its specific properties and reactivity.
Uses
Used in Pharmaceutical Industry:
4-Thiazolecarboxylic acid, 2-[(1R,3R)-3-[[(2S,3S)-2-azido-3-methyl-1-oxopentyl]amino]-1-hydroxy-4-methylpentyl]-, methyl ester is used as a key intermediate in the synthesis of Tubulysin, a potent microtubule-depolymerizing agent with potential anticancer properties. Tubulysin has shown activity against various cancer cell lines, making this intermediate an important component in the development of new cancer therapies.
Additionally, the synthesis of this compound and its derivatives may also contribute to the development of other bioactive molecules with potential applications in medicine, as its unique structure allows for further chemical modifications and exploration of its biological properties.
Check Digit Verification of cas no
The CAS Registry Mumber 921927-93-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,2,1,9,2 and 7 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 921927-93:
(8*9)+(7*2)+(6*1)+(5*9)+(4*2)+(3*7)+(2*9)+(1*3)=187
187 % 10 = 7
So 921927-93-7 is a valid CAS Registry Number.
921927-93-7Relevant articles and documents
Total synthesis of tubulysin U and N14-desacetoxytubulysin H
Cao, Meiqun,Li, Yinghong,Long, Bohua,Tao, Cheng,Wu, Zhengzhi,Zeng, Xiaobin
supporting information, p. 5349 - 5353 (2020/08/03)
A concise and efficient procedure for the total synthesis of tubulysin U and N14-desacetoxytubulysin H has been developed with high stereoselectivity on a gram scale. This synthesis features an elegant cascade one-pot process to install the challenging th
Expedient synthesis of N-methyl tubulysin analogues with high cytotoxicity
Patterson, Andrew W.,Peltier, Hillary M.,Ellman, Jonathan A.
, p. 4362 - 4369 (2008/09/20)
(Chemical Equation Presented) An optimized and highly efficient synthesis of potent, bioactive N-methyl tubulysin analogues 2 and 4 has been achieved with > 40% overall yields. This synthesis represents a significant improvement over previously reported s
