92234-23-6Relevant articles and documents
Synthesis of 4,6-unsubstituted 2-aminodihydropyrimidine-5-carboxylates through sequential staudinger/aza-wittig/cyclization reactions
Nishimura, Yoshio,Cho, Hidetsura
, p. 233 - 237 (2015)
A novel method for constructing the dihydropyrimidine skeleton is developed. The method involves three sequential reactions: (1) the Staudinger reaction of (E)-ethyl 3-azido-2-{[(tert-butoxycarbonyl)amino]methyl}acrylate with triphenylphosphine; (2) aza-W
HIV INTEGRASE INHIBITORS
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Page/Page column 54; 55, (2008/06/13)
Bicyclic pyrazoles of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: (I), wherein Z is O or N(R8); n is an integer equal to zero or 1; and R1, R2, R3, R4, R5, R6, R7 and R8 are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
Synthese et polymerisation de monomeres fluores acryliques substitues en position α. Partie III. Synthese et polymerisation de l'α-heptadecafluoro-undecanoyloxyacrylate d'ethyle
Bessiere, J. M.,Boutevin, B.,El Bachiri, A.,El Harfi, A.
, p. 91 - 96 (2007/10/02)
The synthesis of ethyl α-heptadecafluoro-undecanoyloxyacrylate (3), H2C=C(O-CO-CH2CH2C8F17)CO2CH2CH3, has been performed in three steps starting from ethyl bromopyruvate and heptadecafluoro-undecanoic acid, with an overall yield of c. 70percent.The homopolymerization and copolymerization of 3 have been easily carried out.From the kinetic study of homopolymerization and copolymerization of monomer 3 with styrene, kp2/kTe and r1, r2, the reactivity ratios of the two monomers, can be determined.