922500-95-6Relevant articles and documents
Macrocyclisation of small peptides enabled by oxetane incorporation
Roesner, Stefan,Saunders, George J.,Wilkening, Ina,Jayawant, Eleanor,Geden, Joanna V.,Kerby, Paul,Dixon, Ann M.,Notman, Rebecca,Shipman, Michael
, p. 2465 - 2472 (2019)
Cyclic peptides are an important source of new drugs but are challenging to produce synthetically. We show that head-to-tail peptide macrocyclisations are greatly improved, as measured by isolated yields, reaction rates and product distribution, by substi
Development of oxetane modified building blocks for peptide synthesis
Beadle, Jonathan D.,Clarkson, Guy J.,Raubo, Piotr,Roesner, Stefan,Shipman, Michael,Tam, Leo K. B.,Wilkening, Ina
supporting information, p. 5400 - 5405 (2020/08/03)
The synthesis and use of oxetane modified dipeptide building blocks in solution and solid-phase peptide synthesis (SPPS) is reported. The preparation of building blocks containing non-glycine residues at the N-terminus in a stereochemically controlled man
Method for taking DAST reagent as removing reagent to synthetize conjugated nitroolefin substituted series derivative
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Paragraph 0060; 0061; 0064; 0065, (2018/12/13)
The invention discloses a preparation method of taking a DAST reagent as a removing reagent to synthesize a conjugated nitroolefin substituted series derivative. The preparation method comprises the following steps that a carbonyl compound (compound II) i