92289-44-6

Basic information

• Product Name: 1-(5-Methyl-1-phenyl-1H-1,2,4-triazol-3-yl)ethanone
• Synonyms: 1-(5-Methyl-1-phenyl-1H-1,2,4-triazol-3-yl)ethanone
• CAS NO: 92289-44-6
• Molecular Formula: C₁₁H₁₁N₃O
• Molecular Weight: 201.22454
• Mol File: 92289-44-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 387.894°C at 760 mmHg
• Flash Point: 188.392°C
• Appearance: /
• Density: 1.195g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.614
• CAS DataBase Reference: 1-(5-Methyl-1-phenyl-1H-1,2,4-triazol-3-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-Methyl-1-phenyl-1H-1,2,4-triazol-3-yl)ethanone(92289-44-6)
• EPA Substance Registry System: 1-(5-Methyl-1-phenyl-1H-1,2,4-triazol-3-yl)ethanone(92289-44-6)

Safety Data

• Hazardous Substances Data: 92289-44-6(Hazardous Substances Data)

Usage

Description

1-(5-Methyl-1-phenyl-1H-1,2,4-triazol-3-yl)ethanone, also known as MET, is a chemical compound with the molecular formula C10H10N2O. It is a ketone derivative, and its structure consists of a 1,2,4-triazole ring attached to a phenyl group and a methyl group. MET has been studied for its potential pharmacological properties, including its potential use as a central nervous system stimulant and its antidepressant and anxiolytic effects. It has also been investigated for its potential role in the treatment of neurodegenerative diseases. Additionally, MET has been used as a precursor in the synthesis of other organic compounds.

Uses

Used in Pharmaceutical Industry:
1-(5-Methyl-1-phenyl-1H-1,2,4-triazol-3-yl)ethanone is used as a central nervous system stimulant for its potential to enhance cognitive function and alertness.
1-(5-Methyl-1-phenyl-1H-1,2,4-triazol-3-yl)ethanone is used as an antidepressant for its potential to alleviate symptoms of depression by modulating neurotransmitter levels in the brain.
1-(5-Methyl-1-phenyl-1H-1,2,4-triazol-3-yl)ethanone is used as an anxiolytic for its potential to reduce anxiety and stress by affecting the central nervous system.
1-(5-Methyl-1-phenyl-1H-1,2,4-triazol-3-yl)ethanone is used in the treatment of neurodegenerative diseases for its potential neuroprotective effects and ability to slow down the progression of these diseases.
Used in Chemical Synthesis:
1-(5-Methyl-1-phenyl-1H-1,2,4-triazol-3-yl)ethanone is used as a precursor in the synthesis of other organic compounds for its ability to form various chemical structures and contribute to the development of new pharmaceuticals and other chemical products.

InChI:InChI=1/C11H11N3O/c1-8(15)11-12-9(2)14(13-11)10-6-4-3-5-7-10/h3-7H,1-2H3

Upstream product

• 2208-07-3 ethyl acetimidate hydrochloride 
• 18440-58-9 1-(N-phenylhydrazono)-1-chloropropanone 
• 108-24-7 acetic anhydride 

Relevant articles and documents

One-flask synthesis of 1,3,5-trisubstituted 1,2,4-triazoles from nitriles and hydrazonoyl chlorides via 1,3-dipolar cycloaddition

A one-flask strategy for the synthesis of 1,3,5-trisubstituted 1,2,4-triazoles 4a-s and 8a and b from nitriles 5a-i with N-arylhydrazonoyl hydrochlorides 3a-h and 7a and b under basic conditions was developed. The reaction provided the desired 1,2,4-triazoles in moderate to excellent yields (56-98%), and was applicable to aliphatic and aromatic nitriles as well as N-phenylhydrazonoyl hydrochlorides bearing ester and acetyl functionalities. A 1,3-dipolar cycloaddition between imidate and nitrilimine generated from the respective nitrile and N-arylhydrazonoyl chloride in one flask was proposed for the new transformation.