92362-19-1

Basic information

• Product Name: 2-(But-3-en-1-yl)tetrahydrofuran-2-ol
• Synonyms: 2-(But-3-en-1-yl)tetrahydrofuran-2-ol
• CAS NO: 92362-19-1
• Molecular Formula: C₈H₁₄O₂
• Molecular Weight: 142.19556
• Mol File: 92362-19-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 210.9±33.0 °C(Predicted)
• Appearance: /
• Density: 1.009±0.06 g/cm3(Predicted)
• PKA: 13.17±0.20(Predicted)
• CAS DataBase Reference: 2-(But-3-en-1-yl)tetrahydrofuran-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(But-3-en-1-yl)tetrahydrofuran-2-ol(92362-19-1)
• EPA Substance Registry System: 2-(But-3-en-1-yl)tetrahydrofuran-2-ol(92362-19-1)

Safety Data

• Hazardous Substances Data: 92362-19-1(Hazardous Substances Data)

Usage

General Description

2-(But-3-en-1-yl)tetrahydrofuran-2-ol, also known as THF-2-ol, is a chemical compound with the molecular formula C8H14O2. It is a colorless liquid with a slightly sweet odor. THF-2-ol is commonly used as a solvent in various industrial applications, such as in the production of polymers, resins, and pharmaceuticals. It is also used as a reagent in organic synthesis and as a component in some cleaning products. THF-2-ol is highly flammable and should be handled with caution. It is important to use proper safety measures when working with this chemical, such as wearing protective clothing and working in a well-ventilated area.

Upstream product

• 17605-06-0 ethyl 3-oxohept-6-enoate 
• 121723-80-6 1-Hydroxyoct-7-en-4-one 
• 96-48-0 4-butanolide 
• 7103-09-5 4-but-1-enylmagnesium bromide 
• 92362-17-9 1-(tetrahydropyran-2-yloxy)oct-7-en-4-one 
• 920324-11-4 ethyl 3-oxo-2-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]hept-6-enoate 

Downstream Products

• 5451-15-0 cis-2-methyl-1,6-dioxaspiro<4.4>nonane 
• 5451-15-0 trans-2-methyl-1,6-dioxaspiro<4.4>nonane 
• 5451-15-0 (2S,5R)-2-methyl-1,6-dioxaspiro[4.4]nonane 
• 5451-15-0 (2R,5R)-2-methyl-1,6-dioxaspiro[4.4]nonane 
• 5451-15-0 (2S,5S)-2-methyl-1,6-dioxaspiro[4.4]nonane 
• 5451-15-0 (2R,5S)-2-methyl-1,6-dioxaspiro[4.4]nonane 

Relevant articles and documents

Organoselenium mediated asymmetric cyclizations. Synthesis of enantiomerically pure 1,6-dioxaspiro[4.4]nonanes

The asymmetric cyclization of 1-hydroxyoct-7-en-4-one, promoted by camphorselenenyl tetrafluoroborate, generated from camphor diselenide and silver tetrafluoroborate in dichloromethane at room temperature, afforded a mixture of two diastereoisomeric E- and two diastereoisomeric Z-2-[(camphorseleno)methyl]-1,6-dioxaspiro[4.4]nonanes. These were separated by medium pressure liquid chromatography and then deselenenylated with triphenyltin hydride and AIBN to give enantiomerically pure 2-methyl-1,6-dioxaspiro[4.4]nonanes. The camphorseleno group was also substituted by an allyl function using allyltributyltin in the presence of AIBN.

ALKOXY RADICALS IN ORGANIC SYNTHESIS. A NOVEL APPROACH TO SPIROKETALS

Photolysis of an unsaturated alcohol in the presence of HgO and iodine generates an alkoxy radical which can cyclize to form a five-membered ring ether.If a hemiketal is employed, a spiroketal can be formed in good yield.