92410-11-2Relevant articles and documents
Copper-Promoted O-Arylation of the Phenol Side Chain of Tyrosine Using Triarylbismuthines
Gagnon, Alexandre,Hébert, Martin,Le Roch, Adrien
, p. 5363 - 5367 (2020/08/27)
A general method for the O-arylation of the side chain of tyrosine using triarylbismuth reagents is reported. The reaction is mediated by copper diacetate, operates at 50 °C under oxygen in dichloromethane in the presence of pyridine, shows excellent functional group compatibility, and retains the integrity of the stereogenic center. The protocol was used to arylate the tyrosine residue of dipeptides and tripeptides.