92450-99-2 Usage
Description
MONO-METHYL POLYETHYLENE GLYCOL 20'000 2-(SUCCINYL-AMINO)ETHYL ETHER is a synthetic polymer compound that features a mono-methyl polyethylene glycol (MPEG) chain with a molecular weight of 20,000 and a 2-(succinyl-amino)ethyl ether functional group. This unique structure endows it with versatile properties, making it suitable for various applications in different industries.
Uses
Used in Pharmaceutical Industry:
MONO-METHYL POLYETHYLENE GLYCOL 20'000 2-(SUCCINYL-AMINO)ETHYL ETHER is used as a reactant for the preparation of supramolecular ABC triblock copolymers via orthogonal self-assembly. This process allows for the creation of advanced drug delivery systems with improved properties, such as enhanced stability, controlled release, and targeted delivery.
Used in Biomedical Research:
In biomedical research, MONO-METHYL POLYETHYLENE GLYCOL 20'000 2-(SUCCINYL-AMINO)ETHYL ETHER is used as a reactant for the filamentous condensation of DNA for transfection studies. This application aids in the development of gene therapy techniques and the study of gene expression, providing valuable insights into various biological processes and potential therapeutic targets.
Used in Materials Science:
MONO-METHYL POLYETHYLENE GLYCOL 20'000 2-(SUCCINYL-AMINO)ETHYL ETHER is used as a reactant for the surface functionalization of metal-organic framework (MOF) particles. This surface modification is crucial in biomedical applications, as it allows for the tuning of MOF properties, such as biocompatibility, stability, and drug loading capacity, making them suitable for various therapeutic and diagnostic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 92450-99-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,2,4,5 and 0 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 92450-99:
(7*9)+(6*2)+(5*4)+(4*5)+(3*0)+(2*9)+(1*9)=142
142 % 10 = 2
So 92450-99-2 is a valid CAS Registry Number.
92450-99-2Relevant articles and documents
Hybrids of Small-Molecule CD4 Mimics with Polyethylene Glycol Units as HIV Entry Inhibitors
Kobayakawa, Takuya,Tsuji, Kohei,Konno, Kiju,Himeno, Ai,Masuda, Ami,Yang, Tingting,Takahashi, Kohei,Ishida, Yusuke,Ohashi, Nami,Kuwata, Takeo,Matsumoto, Kaho,Yoshimura, Kazuhisa,Sakawaki, Hiromi,Miura, Tomoyuki,Harada, Shigeyoshi,Matsushita, Shuzo,Tamamura, Hirokazu
supporting information, p. 1481 - 1496 (2021/02/27)
CD4 mimics are small molecules that inhibit the interaction of gp120 with CD4. We have developed several CD4 mimics. Herein, hybrid molecules consisting of CD4 mimics with a long alkyl chain or a PEG unit attached through a self-cleavable linker were synthesized. In anti-HIV activity, modification with a PEG unit appeared to be more suitable than modification with a long alkyl chain. Thus, hybrid molecules of CD4 mimics, with PEG units attached through an uncleavable linker, were developed and showed high anti-HIV activity and low cytotoxicity. In investigation of pharmacokinetics in a rhesus macaque, a hybrid compound had a more effective PK profile than that of the parent compound, and intramuscular injection was a more useful administration route to maintain the high blood concentration of the CD4 mimic than intravenous injection. The presented hybrid molecules of CD4 mimics with a PEG unit would be practically useful when combined with a neutralizing antibody.