93247-78-0

Basic information

• Product Name: Methyl 1H-indole-7-carboxylate
• Synonyms: RARECHEM AL BF 0640;METHYL INDOLE-7-CARBOXYLATE;METHYL 1H-INDOLE-7-CARBOXYLATE;INDOLE-7-CARBOXYLIC ACID METHYL ESTER;7-INDOLECARBOXYLIC ACID METHYL ESTER;1H-INDOLE-7-CARBOXYLIC ACID METHYL ESTER;Methyl 1H-indole-7-c;7-(Methoxycarbonyl)-1H-indole
• CAS NO: 93247-78-0
• Molecular Formula: C₁₀H₉NO₂
• Molecular Weight: 175.18
• EINECS: 1308068-626-2
• Product Categories: blocks;Carboxes;IndolesOxindoles;Indoles and derivatives;Indole
• Mol File: 93247-78-0.mol
• Article Data: 14

Chemical Properties

• Melting Point: 47-48°C
• Boiling Point: 331.7 °C at 760 mmHg
• Flash Point: 154.4 °C
• Appearance: /Solid
• Density: 1.253 g/cm³
• Vapor Pressure: 0.000153mmHg at 25°C
• Refractive Index: 1.639
• Storage Temp.: Store below +30°C.
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 15.42±0.30(Predicted)
• CAS DataBase Reference: Methyl 1H-indole-7-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 1H-indole-7-carboxylate(93247-78-0)
• EPA Substance Registry System: Methyl 1H-indole-7-carboxylate(93247-78-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-37/39
• WGK Germany: WGK 3 highly water endangering
• HazardClass: IRRITANT
• Hazardous Substances Data: 93247-78-0(Hazardous Substances Data)

Usage

Description

Methyl 1H-indole-7-carboxylate is an organic compound that serves as a key intermediate in the synthesis of various pharmaceuticals and biologically active molecules. It is characterized by its indole ring structure and carboxylate functional group, which contribute to its unique chemical properties and potential applications in medicinal chemistry.

Uses

Used in Pharmaceutical Industry:
Methyl 1H-indole-7-carboxylate is used as a key intermediate in the synthesis of inhibitors of CD38, an enzyme involved in various cellular processes and implicated in the pathophysiology of several diseases, including cancer. The development of CD38 inhibitors using Methyl 1H-indole-7-carboxylate as a starting material can lead to novel therapeutic agents for the treatment of cancer, offering new treatment options and improving patient outcomes.

InChI:InChI=1/C10H9NO2/c1-13-10(12)8-4-2-3-7-5-6-11-9(7)8/h2-6,11H,1H3

Upstream product

• 67-56-1 methanol 
• 1670-83-3 1H-Indole-7-carboxylic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 104670-71-5 methyl 3-bromo-2-nitrobenzoate 
• 5437-38-7 3-methyl-2-nitrobenzoic acid 
• 132874-06-7 methyl 3-(bromomethyl)-2-nitrobenzoate 
• 5471-82-9 methyl 3-methyl-2-nitrobenzoate 
• 577-19-5 2-nitrophenyl bromide 
• 51417-51-7 7-bromo-1H-indole 
• 201230-82-2 carbon monoxide 
• 126759-37-3 methyl 3-ethenyl-2-nitrobenzoate 
• 79-22-1 methyl chloroformate 
• 126759-45-3 <(3-methoxycarbonyl-2-nitrophenyl)methyl>-1,3-dioxane 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 167479-16-5 1-methylindolyl-7-carboxylic acid 
• 189634-92-2 1-Benzyl-1H-indole-7-carboxylic acid methyl ester 
• 312915-01-8 methyl 3-dimethylaminomethylindole-7-carboxylate 
• 1074-87-9 indole-7-methanol 
• 729614-30-6 methyl 5-benzyl-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-4-carboxylate 
• 1027787-38-7 methyl 1-benzyl-3-iodo-1H-indole-7-carboxylate 
• 917562-23-3 1-(tert-butyl) 7-methyl 1H-indole-1,7-dicarboxylate 
• 955039-54-0 methyl 4-{(1S)-1-[({1-[3-(trifluoromethyl)benzyl]-1H-indol-7-yl}carbonyl)amino]ethyl}benzoate 
• 1238214-74-8 1-[3-(trifluoromethyl)benzyl]-1H-indole-7-carboxylic acid 
• 955039-58-4 1-(3-chlorophenyl)-1H-indole-7-carboxylic acid 

Relevant articles and documents

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