936343-08-7

Basic information

• Product Name: 5-bromo-2-(4-fluoro-benzyloxy)-pyridine
• Synonyms: 5-bromo-2-(4-fluoro-benzyloxy)-pyridine
• CAS NO: 936343-08-7
• Molecular Formula: C₁₂H₉BrFNO
• Molecular Weight: 282
• Mol File: 936343-08-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-bromo-2-(4-fluoro-benzyloxy)-pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-2-(4-fluoro-benzyloxy)-pyridine(936343-08-7)
• EPA Substance Registry System: 5-bromo-2-(4-fluoro-benzyloxy)-pyridine(936343-08-7)

Safety Data

• Hazardous Substances Data: 936343-08-7(Hazardous Substances Data)

Upstream product

• 13466-38-1 5-bromopyridin-2(1H)-one 
• 459-46-1 4-Fluorobenzyl bromide 
• 766-11-0 5-bromo-2-fluoropyridine 
• 459-56-3 4-fluorobenzylic alcohol 
• 624-28-2 2,5-dibromopyridine 

Downstream Products

• 936343-09-8 6-(4-fluoro-benzyloxy)-pyridine-3-carbaldehyde 

Relevant articles and documents

ANTIBACTERIAL COMPOUNDS

The present invention relates to compounds of general formula (II),to compositions comprising these compounds and to methods of treating Enterobacteriaceae bacterial diseases and infections using the compounds. The compounds find application in the treatment of infection with, and diseases caused by, Enterobacteriaceae.

Mild and Regioselective N-Alkylation of 2-Pyridones in Water

A mild and regioselective N-alkylation reaction of 2-pyridones in water has been developed. Tween 20 (2% w/w) was added to create a micellar system for improved solubility of starting materials, which leads to enhanced reaction rates. The protocol demonstrated a wide substrate scope with good isolated yields (40-94%) for all of the 24 examples evaluated. High regioselectivity favoring N-alkylation over O-alkylation was observed for benzyl halides (>5:1), primary alkyl halides (>6:1), and bulky and less reactive secondary alkyl halides (>2.4:1).