94-31-5Relevant articles and documents
A 4 - (N - methyl - N - sulfo ethyl) amino formaldehyde sodium synthesis method
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Paragraph 0031-0050, (2018/06/19)
The present invention discloses a 4-(N-methyl-N-sulfoethyl)aminobenzaldehyde sodium salt synthesis method, which comprises: adding N-methyl-N-hydroxyethyl aniline and a chlorine-containing oxide to an organic solvent to carry out a substitution reaction so as to generate N-methyl-N-chloroethylaniline, carrying out a Vilsmeier-Haack reaction of the N-methyl-N-chloroethylaniline, disubstituted formamide and phosphorus oxychloride to generate N-methyl-N-chloroethyl-4-aminobenzaldehyde, and carrying out a sulfonation reaction of the N-methyl-N-chloroethyl-4-aminobenzaldehyde and a sulfonation agent in an alkaline solution to generate the 4-(N-methyl-N-sulfoethyl)aminobenzaldehyde sodium salt. The method of the present invention has characteristics of cheap and readily available raw materials and simple process, and is suitable for large-scale industrial production.
Nucleic acid-immobilized substrate
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, (2008/06/13)
By immobilizing identical or different nucleic acids in a plurality of dot-like areas on a carrier which comprises a base material and compound carried on the base material, the compound having one or more alkylating groups, through intermediary of the alkylating group, a nucleic acid-immobilized substrate on which nucleic acids are firmly immobilized in fine dot area without reference to chain length of nucleic acids is provided, which enables efficiently introducing the nucleic acids onto the base material in a simple manner and can be produced with a simple apparatus.