94-64-4

Basic information

• Product Name: N-(2-CHLOROBENZYL)-N-METHYLAMINE
• Synonyms: TIMTEC-BB SBB010370;ASINEX-REAG BAS 16578945;AKOS BC-2744;(2-CHLORO-BENZYL)-METHYL-AMINE;2-CHLORO-N-METHYLBENZYLAMINE;2-Chloro-N-methylbenzenemethanamine;N-Methyl-2-chlorobenzylamine;N-(2-Chlorobenzyl)-N-methylamine ,97%
• CAS NO: 94-64-4
• Molecular Formula: C₈H₁₀ClN
• Molecular Weight: 155.62
• EINECS: 202-350-1
• Product Categories: Polyamines;Amines;C8;Nitrogen Compounds
• Mol File: 94-64-4.mol
• Article Data: 7

Chemical Properties

• Melting Point: 0°C
• Boiling Point: 225-226 °C(lit.)
• Flash Point: 208 °F
• Appearance: pale yellow oil.
• Density: 1.110 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.232mmHg at 25°C
• Refractive Index: n20/D 1.5430(lit.)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 9.01±0.10(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: N-(2-CHLOROBENZYL)-N-METHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-CHLOROBENZYL)-N-METHYLAMINE(94-64-4)
• EPA Substance Registry System: N-(2-CHLOROBENZYL)-N-METHYLAMINE(94-64-4)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-37/38-41
• Safety Statements: 26-36
• RIDADR: 2735
• WGK Germany: 3
• TSCA: Yes
• HazardClass: IRRITANT
• Hazardous Substances Data: 94-64-4(Hazardous Substances Data)

Usage

Uses

2-Chloro-N-methylbenzylamine (N-(2-chlorobenzyl)-N-methylamine) may be used in chemical synthesis studies.

InChI:InChI=1/C8H10ClN/c1-10-6-7-4-2-3-5-8(7)9/h2-5,10H,6H2,1H3/p+1

Upstream product

• 611-17-6 1-bromomethyl-2-chlorobenzene 
• 74-89-5 methylamine 
• 89-98-5 2-chloro-benzaldehyde 
• 124-40-3 dimethyl amine 
• 611-19-8 1-chloro-2-(chloromethyl)benzene 
• 89-97-4 2-CHLOROBENZYLAMINE 
• 475201-00-4 methyl N-(2-chlorobenzyl)carbamate 
• 593-51-1 methylamine hydrochloride 
• 17972-08-6 N-(2-chlorophenylmethylene)methanamine 

Downstream Products

• 65763-35-1 N-(2-Chlorbenzyl)-N-methyl-aminoacetophenon 
• 112780-97-9 3-[(2-Chloro-benzyl)-methyl-amino]-1-phenyl-propan-1-one 
• 253129-45-2 N-(2-chlorobenzyl)-N-methyl acetoacetamide 
• 1092060-47-3 C₂₅H₂₄ClFN₂ 
• 1092060-59-7 C₂₆H₂₆ClFN₂ 
• 1174903-42-4 3-[[(2-chlorobenzyl)-methyl-amino]methyl]-5-(pyridin-4-yl)-1,3,4-oxadiazol-2(3H)-one 
• 76532-15-5 N⁶-(2-Chloro-benzyl)-N⁶-methyl-pteridine-2,4,6-triamine 
• 93653-43-1 2-[(2-Chloro-benzyl)-methyl-amino]-6,6-dimethyl-4-oxo-cyclohex-2-enecarbonitrile 
• 55245-87-9 C₉H₉Cl₂NO 
• 17683-37-3 2-[(2-chloro-benzyl)-methyl-amino]-ethanol 
• 65763-39-5 (2-chloro-benzyl)-methyl-(4-nitro-benzyl)-amine 

Relevant articles and documents

Heterogeneous Catalyzed Chemoselective Reductive Amination of Halogenated Aromatic Aldehydes

The chemoselective conversion of a specific functional group in a multifunctional substrate is of great importance in the chemical industry to obtain cost efficient, sustainable and waste free processes. This work focuses on the chemoselective amination of halogenated aromatic aldehydes with dimethyl amine towards halogenated aromatic amines, a raw material used in the production of for example agrochemical active ingredients. It was found that by combining palladium, a metal known for dehalogenation reactions, and copper, known for its direct hydrogenation of aldehydes to alcohols, in one heterogeneous bimetallic catalyst, a synergistic effect is obtained. By depositing copper onto a palladium on carbon catalyst with a Cu/Pd ratio of at least 1 : 1, the yield could be increased from 66 % (Pd/C) to 98 % (PdCu/C). Moreover, this highly active and stable catalyst also showed suppressed dehalogenation side-reactions in several other chemical conversions such as hydrogenation of nitro functional groups and hydrogenation of aldehydes.

Antimycobacterial activity of new 3,5-disubstituted 1,3,4-oxadiazol-2(3H)-one derivatives. Molecular modeling investigations

3H-1,3,4-Oxadiazol-2-one derivatives were synthesized and tested for their in vitro antimycobacterial activity. Oxadiazolone derivatives showed an interesting antimycobacterial activity against the reference strain of Mycobacterium tuberculosis H37Rv. Molecular modeling investigations were performed and showed that the active compounds possess all necessary features to target the protein active site of the mycobacterial cytochrome P450-dependent sterol 14α-demethylase in the sterol biosynthesis pathway as the calculated free energy of binding were in agreement with the corresponding MIC values.

Intramolecular addition of stabilized enolates to (η6-arene)ruthenium complexes: Synthesis of Ru-coordinated azaspirocycles

(formula presented) Stabilized enolates attached to cationic (arene)RuIICp complexes via an amide linkage were found to participate in nucleophilic aromatic addition reactions resulting in the formation of novel cyclohexadienyl-Ru azaspirocycles. Enolate addition to the activated arene ring was found to proceed with complete stereoselectivity.