941172-12-9

Basic information

• Product Name: 6-[5-(anilinocarbonyl)-6-methyl-2-oxo-4-phenyl-3,4-dihydropyrimidin-1(2H)-yl]hexanoic acid
• Synonyms: 6-[5-(anilinocarbonyl)-6-methyl-2-oxo-4-phenyl-3,4-dihydropyrimidin-1(2H)-yl]hexanoic acid
• CAS NO: 941172-12-9
• Molecular Weight: 421.496
• Mol File: 941172-12-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-[5-(anilinocarbonyl)-6-methyl-2-oxo-4-phenyl-3,4-dihydropyrimidin-1(2H)-yl]hexanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-[5-(anilinocarbonyl)-6-methyl-2-oxo-4-phenyl-3,4-dihydropyrimidin-1(2H)-yl]hexanoic acid(941172-12-9)
• EPA Substance Registry System: 6-[5-(anilinocarbonyl)-6-methyl-2-oxo-4-phenyl-3,4-dihydropyrimidin-1(2H)-yl]hexanoic acid(941172-12-9)

Safety Data

• Hazardous Substances Data: 941172-12-9(Hazardous Substances Data)

Upstream product

• 1468-42-4 6-ureidohexanoic acid 
• 100-52-7 benzaldehyde 
• 102-01-2 N-phenylacetoacetamide 

Relevant articles and documents

Protecting group free synthesis of carboxyl-substituted dihydropyrimidines through Biginelli reaction

Chlorotrimethylsilane-promoted Biginelli-type reaction of benzaldehyde, acetoacetic acid derivatives, and various carboxyl-containing ureas was explored. It was found that the steric load of the urea substituents influenced strongly the reaction outcome; in particular, the method was efficient only in the case of unbranched mono-substituted ureas bearing either aliphatic or aromatic groups. The method allows performing a one-pot, protecting group free synthesis of dihydropyrimidines possessing carboxylic functionality.